PMID- 18260323
OWN - NLM
STAT- MEDLINE
DCOM- 20080321
LR  - 20110727
IS  - 0047-1852 (Print)
IS  - 0047-1852 (Linking)
VI  - 66
IP  - 2
DP  - 2008 Feb
TI  - [Regulation of proinflammatory cytokine cascade in Kawasaki disease].
PG  - 258-64
AB  - Kawasaki disease (KD) is one of the cytokine-associated diseases, which is 
      systemic inflammatory response syndrome. Tumor necrosis factor-alpha(TNF-alpha), 
      as proinflammatory cytokine, plays an important role in the vascular injury of 
      KD. Nuclear factor kappa B (NF-kappaB) is a pivotal transcription factor for 
      genes that encode the proinflammatory cytokines, chemokines and adhesion 
      molecules that mediate inflammation. We have already reported the activation of 
      NF-kappaB in peripheral blood mononuclear cells with the dominant of 
      monocytes/macrophages. There is ample evidence of a central role of peripheral 
      blood monocytes/macrophages during acute KD. The standard therapy of KD is 
      intravenous immunoglobulin (IVIG). According to circumstances, corticosteroid has 
      been used to treat the KD patients. Recently, it has been reported that new 
      biologic therapy, such as anti-TNF agents are useful for the patients who failed 
      to respond to an initial IVIG. We focus on the different mechanism of IVIG, 
      corticosteroid and anti-TNF agents with regard to the anti-inflammatory effects.
FAU - Furukawa, Susumu
AU  - Furukawa S
AD  - Department of Pediatrics, Yamaguchi University Graduate School of Medicine.
FAU - Matsubara, Tomoyo
AU  - Matsubara T
FAU - Ichiyama, Takashi
AU  - Ichiyama T
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PT  - Review
PL  - Japan
TA  - Nihon Rinsho
JT  - Nihon rinsho. Japanese journal of clinical medicine
JID - 0420546
RN  - 0 (Cytokines)
RN  - 0 (Immunoglobulins, Intravenous)
RN  - 0 (NF-kappa B)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Cytokines/*blood
MH  - Humans
MH  - Immunoglobulins, Intravenous/therapeutic use
MH  - Mucocutaneous Lymph Node Syndrome/*blood/drug therapy
MH  - NF-kappa B/blood
MH  - Tumor Necrosis Factor-alpha/blood
RF  - 19
EDAT- 2008/02/12 09:00
MHDA- 2008/03/22 09:00
CRDT- 2008/02/12 09:00
PHST- 2008/02/12 09:00 [pubmed]
PHST- 2008/03/22 09:00 [medline]
PHST- 2008/02/12 09:00 [entrez]
PST - ppublish
SO  - Nihon Rinsho. 2008 Feb;66(2):258-64.