PMID- 18261181
OWN - NLM
STAT- MEDLINE
DCOM- 20080418
LR  - 20230124
IS  - 1600-6143 (Electronic)
IS  - 1600-6135 (Linking)
VI  - 8
IP  - 3
DP  - 2008 Mar
TI  - Human herpesvirus-8 (HHV-8)-associated primary effusion lymphoma in two renal 
      transplant recipients receiving rapamycin.
PG  - 707-10
LID - 10.1111/j.1600-6143.2007.02110.x [doi]
AB  - The Akt/mammalian target of rapamycin (mTOR) signaling cascade has been 
      demonstrated to be constitutively activated in several malignancies, including 
      Kaposi sarcoma (KS) and human herpesvirus-8 (HHV-8)-associated primary effusion 
      lymphoma (PEL). In organ transplant recipients, therapeutic change from 
      cyclosporin to the mTOR inhibitor rapamycin can lead to regression of KS lesions. 
      Recent experiments using PEL cell lines and murine xenograft PEL models suggested 
      that rapamycin could inhibit the growth of PEL cells. In the present report, we 
      describe the cases of two HIV-1-negative males of African origin who underwent 
      renal transplantation and developed PEL while receiving rapamycin as 
      immunosuppressive treatment. Both patients were retrospectively found to be HHV-8 
      seropositive before renal transplantation. The present case report suggests that 
      rapamycin may not protect HHV-8-infected renal transplant recipients from 
      occurrence of PEL or progression of pre-existing PEL.
FAU - Boulanger, E
AU  - Boulanger E
AD  - Departement d'Immunologie Clinique, Hopital Saint-Louis, Assistance 
      Publique-Hopitaux de Paris (AP-HP), Paris, France. 
      emmanuelle.boulanger@sls.aphp.fr
FAU - Afonso, P V
AU  - Afonso PV
FAU - Yahiaoui, Y
AU  - Yahiaoui Y
FAU - Adle-Biassette, H
AU  - Adle-Biassette H
FAU - Gabarre, J
AU  - Gabarre J
FAU - Agbalika, F
AU  - Agbalika F
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080205
PL  - United States
TA  - Am J Transplant
JT  - American journal of transplantation : official journal of the American Society of 
      Transplantation and the American Society of Transplant Surgeons
JID - 100968638
RN  - 0 (Immunosuppressive Agents)
RN  - W36ZG6FT64 (Sirolimus)
SB  - IM
MH  - Fatal Outcome
MH  - Herpesviridae Infections/diagnosis/*drug therapy
MH  - *Herpesvirus 8, Human/isolation & purification
MH  - Humans
MH  - Immunosuppressive Agents/*therapeutic use
MH  - *Kidney Transplantation
MH  - Lymphoma, Primary Effusion/diagnosis/*drug therapy/virology
MH  - Male
MH  - Middle Aged
MH  - Sirolimus/*therapeutic use
MH  - Treatment Failure
EDAT- 2008/02/12 09:00
MHDA- 2008/04/19 09:00
CRDT- 2008/02/12 09:00
PHST- 2008/02/12 09:00 [pubmed]
PHST- 2008/04/19 09:00 [medline]
PHST- 2008/02/12 09:00 [entrez]
AID - S1600-6135(22)05739-2 [pii]
AID - 10.1111/j.1600-6143.2007.02110.x [doi]
PST - ppublish
SO  - Am J Transplant. 2008 Mar;8(3):707-10. doi: 10.1111/j.1600-6143.2007.02110.x. 
      Epub 2008 Feb 5.