PMID- 18261570
OWN - NLM
STAT- MEDLINE
DCOM- 20080501
LR  - 20080211
IS  - 0041-1345 (Print)
IS  - 0041-1345 (Linking)
VI  - 40
IP  - 1
DP  - 2008 Jan-Feb
TI  - Offspring-to-mother and husband-to-wife renal transplantation: a single-center 
      experience.
PG  - 140-2
LID - 10.1016/j.transproceed.2007.11.062 [doi]
AB  - BACKGROUND: It has been demonstrated that graft survival rates of 
      offspring-to-mother and husband-to-wife renal transplants are equivalent to those 
      of other living donors. Although the vast majority of these transplants proceed 
      without incident, hyperacute rejection can result from an anamnestic reaction 
      subsequent to the in utero exposure of the mother to human leukocyte antigen 
      (HLA) of the fetus with sensitization developing during the pregnancy. PATIENTS 
      AND METHODS: Among 1350 renal transplants performed at our center, 12 
      corresponded to offspring-to-mother (G1) and 9 were husband-to-wife 
      transplantations (G2). All recipients were multiparous (2 to 5 children). We 
      compared these patients with other multiparous women (n = 150) who received 
      grafts from living unrelated donors (G3). RESULTS: Two subjects in G1 (16.6%), 
      two in G2 (22.2%), and none in G3 developed hyperacute rejection, which led to 
      graft loss. One, 3-, and 5-year patient and graft survival rates were different 
      between the remaining patients. CONCLUSIONS: Our limited experience suggested 
      that, for some women, pregnancy is in fact a sensitizing event. A 
      pretransplantation cross-match testing negative result was by no means an 
      absolute guarantee that an adverse anamnestic immunological event would not 
      occur.
FAU - Ghafari, A
AU  - Ghafari A
AD  - Nephrology Department, Emam Hospital, Urmia University of Medical Sciences, 
      Urmia, Iran. ghaf_ali@yahoo.com
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Transplant Proc
JT  - Transplantation proceedings
JID - 0243532
SB  - IM
MH  - Adult
MH  - Female
MH  - Graft Rejection/epidemiology
MH  - Graft Survival
MH  - Humans
MH  - Kidney Transplantation/mortality/*physiology
MH  - *Living Donors
MH  - Male
MH  - Middle Aged
MH  - *Nuclear Family
MH  - Parent-Child Relations
MH  - Retrospective Studies
MH  - Spouses
MH  - Survival Analysis
MH  - Treatment Outcome
EDAT- 2008/02/12 09:00
MHDA- 2008/05/02 09:00
CRDT- 2008/02/12 09:00
PHST- 2008/02/12 09:00 [pubmed]
PHST- 2008/05/02 09:00 [medline]
PHST- 2008/02/12 09:00 [entrez]
AID - S0041-1345(07)01454-6 [pii]
AID - 10.1016/j.transproceed.2007.11.062 [doi]
PST - ppublish
SO  - Transplant Proc. 2008 Jan-Feb;40(1):140-2. doi: 
      10.1016/j.transproceed.2007.11.062.