PMID- 18262454
OWN - NLM
STAT- MEDLINE
DCOM- 20081104
LR  - 20080609
IS  - 1098-612X (Print)
IS  - 1098-612X (Linking)
VI  - 10
IP  - 3
DP  - 2008 Jul
TI  - Resolution of renal adenocarcinoma-induced secondary inappropriate polycythaemia 
      after nephrectomy in two cats.
PG  - 264-8
LID - 10.1016/j.jfms.2007.11.006 [doi]
AB  - Two cases of secondary, inappropriate polycythaemia caused by renal 
      adenocarcinoma in domestic shorthair cats, are described. The cats were 9 and 12 
      years old and both were presented because of generalised seizures presumably due 
      to hyperviscosity. Both cats had a markedly increased haematocrit (0.770 and 
      0.632 l/l) and thrombocytosis (744 x 10(9)/l and 926 x 10(9)/l). An abdominal 
      ultrasound revealed a mass in the cranial pole of one kidney in both cats. Serum 
      erythropoietin (EPO) concentration was within the reference interval (RI) in both 
      cats but was inappropriately high considering the markedly increased haematocrit. 
      The cats were initially stabilised and managed by multiple phlebotomies and 
      intravenous fluid therapy and underwent nephrectomy of the affected kidney later 
      on. Both the polycythaemia and thrombocytosis resolved following surgery. 
      Postoperative serum EPO concentration, measured in one cat, decreased markedly. 
      Histopathology of the affected kidneys confirmed a diagnosis of renal 
      adenocarcinoma. Both cats were stable for an 8-month follow-up period; however, 
      one cat had developed a stable chronic kidney disease (CKD), while the other was 
      represented 8 months postoperatively due to dyspnoea, and had radiographic 
      evidence of lung metastasis, presumably because of the spread of the original 
      renal tumour and was euthanased. Initial stabilisation of polycythaemic cats 
      should include multiple phlebotomies. Nephrectomy should be considered in cats 
      with secondary, inappropriate, renal adenocarcinoma-related polycythaemia when 
      only one kidney is affected by the tumour, and provided that the other kidney's 
      function is satisfactory. Nephrectomy should be expected to resolve the 
      polycythaemia and lead to normalisation of serum EPO concentration.
FAU - Klainbart, Sigal
AU  - Klainbart S
AD  - Koret School of Veterinary Medicine, The Hebrew University of Jerusalem, Rehovot, 
      Israel.
FAU - Segev, Gilad
AU  - Segev G
FAU - Loeb, Emmanuel
AU  - Loeb E
FAU - Melamed, Dana
AU  - Melamed D
FAU - Aroch, Itamar
AU  - Aroch I
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20080208
PL  - England
TA  - J Feline Med Surg
JT  - Journal of feline medicine and surgery
JID - 100897329
SB  - IM
MH  - Animals
MH  - Carcinoma, Renal Cell/surgery/*veterinary
MH  - Cat Diseases/*pathology/*surgery
MH  - Cats
MH  - Female
MH  - Kidney Failure, Chronic/veterinary
MH  - Kidney Neoplasms/surgery/*veterinary
MH  - Nephrectomy/adverse effects/*veterinary
MH  - Polycythemia/etiology/*veterinary
EDAT- 2008/02/12 09:00
MHDA- 2008/11/05 09:00
CRDT- 2008/02/12 09:00
PHST- 2007/11/26 00:00 [accepted]
PHST- 2008/02/12 09:00 [pubmed]
PHST- 2008/11/05 09:00 [medline]
PHST- 2008/02/12 09:00 [entrez]
AID - S1098-612X(07)00214-8 [pii]
AID - 10.1016/j.jfms.2007.11.006 [doi]
PST - ppublish
SO  - J Feline Med Surg. 2008 Jul;10(3):264-8. doi: 10.1016/j.jfms.2007.11.006. Epub 
      2008 Feb 8.