PMID- 18262708
OWN - NLM
STAT- MEDLINE
DCOM- 20080722
LR  - 20220408
IS  - 0278-5846 (Print)
IS  - 0278-5846 (Linking)
VI  - 32
IP  - 4
DP  - 2008 May 15
TI  - Anticonvulsive effects of intracerebroventricular administration of rutin in 
      rats.
PG  - 989-93
LID - 10.1016/j.pnpbp.2008.01.011 [doi]
AB  - Various synthetic derivatives of natural flavonoids are known to have neuroactive 
      properties. The aim of the present study was to investigate the anticonvulsant 
      effects of rutin (3, 3', 4', 5, 7-pentahydrohyflavone-3-rhamnoglucoside), a 
      flavonoid which is an important dietary constituent of food and plant-based 
      beverages. To this end, we assessed the anticonvulsant effects of rutin in rats 
      treated with pentylenetetrazole (PTZ) (90 mg/kg, i.p.) and sought to clarify this 
      mechanism. Intracerebroventricular (i.c.v.) injection of rutin dose-dependently 
      affected minimal clonic seizures (MCS) and generalized tonic-clonic seizures 
      (GTCS) induced by PTZ, through increments in seizure onset. Additionally, 
      pretreatment with flumazenil (5 nM, i.c.v.) abolished the anticonvulsant effects 
      of rutin during the onset of both seizures. These results indicate that rutin has 
      anticonvulsant effects in the brain, possibly through positive allosteric 
      modulation of the GABA(A) receptor complex via interaction at the benzodiazepine 
      site.
FAU - Nassiri-Asl, Marjan
AU  - Nassiri-Asl M
AD  - Department of Pharmacology, School of Medical Sciences, Qazvin University, 
      Qazvin, Iran. marjannassiriaslm@gmail.com
FAU - Shariati-Rad, Schwann
AU  - Shariati-Rad S
FAU - Zamansoltani, Farzaneh
AU  - Zamansoltani F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080119
PL  - England
TA  - Prog Neuropsychopharmacol Biol Psychiatry
JT  - Progress in neuro-psychopharmacology & biological psychiatry
JID - 8211617
RN  - 0 (Anticonvulsants)
RN  - 0 (Convulsants)
RN  - 0 (GABA Antagonists)
RN  - 0 (GABA Modulators)
RN  - 40P7XK9392 (Flumazenil)
RN  - 56-12-2 (gamma-Aminobutyric Acid)
RN  - 5G06TVY3R7 (Rutin)
RN  - WM5Z385K7T (Pentylenetetrazole)
SB  - IM
MH  - Animals
MH  - *Anticonvulsants
MH  - Brain/pathology
MH  - Convulsants
MH  - Dose-Response Relationship, Drug
MH  - Epilepsy, Tonic-Clonic/chemically induced/physiopathology
MH  - Flumazenil/pharmacology
MH  - GABA Antagonists/pharmacology
MH  - GABA Modulators/pharmacology
MH  - Injections, Intraventricular
MH  - Male
MH  - Pentylenetetrazole
MH  - Rats
MH  - Rats, Wistar
MH  - Rutin/administration & dosage/*pharmacology
MH  - Seizures/chemically induced/pathology/prevention & control
MH  - gamma-Aminobutyric Acid/physiology
EDAT- 2008/02/12 09:00
MHDA- 2008/07/23 09:00
CRDT- 2008/02/12 09:00
PHST- 2007/11/19 00:00 [received]
PHST- 2008/01/14 00:00 [revised]
PHST- 2008/01/14 00:00 [accepted]
PHST- 2008/02/12 09:00 [pubmed]
PHST- 2008/07/23 09:00 [medline]
PHST- 2008/02/12 09:00 [entrez]
AID - S0278-5846(08)00037-7 [pii]
AID - 10.1016/j.pnpbp.2008.01.011 [doi]
PST - ppublish
SO  - Prog Neuropsychopharmacol Biol Psychiatry. 2008 May 15;32(4):989-93. doi: 
      10.1016/j.pnpbp.2008.01.011. Epub 2008 Jan 19.