PMID- 18263664
OWN - NLM
STAT- MEDLINE
DCOM- 20080806
LR  - 20131121
IS  - 1545-7214 (Electronic)
IS  - 1064-7481 (Linking)
VI  - 16
IP  - 4
DP  - 2008 Apr
TI  - The brain-derived neurotrophic factor VAL66MET polymorphism and cerebral white 
      matter hyperintensities in late-life depression.
PG  - 263-71
LID - 10.1097/JGP.0b013e3181591c30 [doi]
AB  - OBJECTIVE: In animal models, brain-derived neurotrophic factor (BDNF) appears to 
      protect against cerebral ischemia. The authors examined whether the BDNF Val66Met 
      polymorphism, which affects BDNF distribution, was associated with greater 
      volumes of hyperintense lesions as detected on magnetic resonance imaging in a 
      cohort of depressed and nondepressed elders. DESIGN: Subjects completed 
      cross-sectional assessments, including clinical evaluation and a brain magnetic 
      resonance imaging scan, and provided blood samples for Val66Met genotyping. 
      SETTING: The study was conducted at a university-based academic hospital. 
      PARTICIPANTS: Participants included 199 depressed and 113 nondepressed subjects 
      aged 60 years or older. MEASUREMENT: Hyperintensity lesion volumes were measured 
      using a semiautomated segmentation procedure. Statistical models examined the 
      relationship between genotype and lesion volume while controlling for depression, 
      presence of hypertension, age, and sex. RESULTS: After controlling for 
      covariates, Met66 allele carriers exhibited significantly greater white matter 
      hyperintensity volumes (F(1,311) = 4.09, p = 0.0442). This effect was independent 
      of a diagnosis of depression or report of hypertension. Genotype was not 
      significantly related to gray matter hyperintensity volume (F(1,311) = 1.14, p = 
      0.2871). CONCLUSIONS: The BDNF Met66 allele is associated with greater white 
      matter hyperintensity volumes in older individuals. Further work is needed to 
      determine how this may be associated with other clinically relevant findings in 
      late-life depression.
FAU - Taylor, Warren D
AU  - Taylor WD
AD  - Neuropsychiatric Imaging Research Laboratory, and the Department of Psychiatry, 
      Duke University Medical Center, Durham, NC 27710, USA. Taylo066@mc.duke.edu
FAU - Zuchner, Stephan
AU  - Zuchner S
FAU - McQuoid, Douglas R
AU  - McQuoid DR
FAU - Payne, Martha E
AU  - Payne ME
FAU - MacFall, James R
AU  - MacFall JR
FAU - Steffens, David C
AU  - Steffens DC
FAU - Speer, Marcy C
AU  - Speer MC
FAU - Krishnan, K Ranga R
AU  - Krishnan KR
LA  - eng
GR  - ES11961/ES/NIEHS NIH HHS/United States
GR  - K23 MH65939/MH/NIMH NIH HHS/United States
GR  - P50 MH60451/MH/NIMH NIH HHS/United States
GR  - R01 MH54846/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20080208
PL  - England
TA  - Am J Geriatr Psychiatry
JT  - The American journal of geriatric psychiatry : official journal of the American 
      Association for Geriatric Psychiatry
JID - 9309609
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - AE28F7PNPL (Methionine)
RN  - HG18B9YRS7 (Valine)
SB  - IM
MH  - Age of Onset
MH  - Aged
MH  - Amino Acid Substitution
MH  - Brain/*pathology
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Cross-Sectional Studies
MH  - Depression/*genetics/pathology
MH  - Female
MH  - Genotype
MH  - Humans
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - *Methionine
MH  - *Polymorphism, Single Nucleotide
MH  - *Valine
EDAT- 2008/02/12 09:00
MHDA- 2008/08/07 09:00
CRDT- 2008/02/12 09:00
PHST- 2008/02/12 09:00 [pubmed]
PHST- 2008/08/07 09:00 [medline]
PHST- 2008/02/12 09:00 [entrez]
AID - JGP.0b013e3181591c30 [pii]
AID - 10.1097/JGP.0b013e3181591c30 [doi]
PST - ppublish
SO  - Am J Geriatr Psychiatry. 2008 Apr;16(4):263-71. doi: 
      10.1097/JGP.0b013e3181591c30. Epub 2008 Feb 8.