PMID- 18264709
OWN - NLM
STAT- MEDLINE
DCOM- 20090127
LR  - 20231213
IS  - 0172-8172 (Print)
IS  - 0172-8172 (Linking)
VI  - 28
IP  - 9
DP  - 2008 Jul
TI  - Modulation of the Fcgamma receptors induced by anti-Ro and anti-La 
      autoantibodies: observations in salivary gland cells.
PG  - 943-8
LID - 10.1007/s00296-008-0536-5 [doi]
AB  - Only few reports have shown protein expression of the Fcgamma receptors 
      (FcgammaRs) molecules on human salivary gland cells. In this study we investigate 
      a possible upregulation of FcgammaRs following anti-Ro and anti-La autoantibodies 
      treatment. Anti-Ro and anti-La autoantibodies were purified from IgG fractions 
      obtained from 14 patients with primary Sjogren's syndrome (SS), using Sepharose 
      4B-Ro and Sepharose 4B-La affinity columns. Flow cytometry and RT-PCR were used 
      to study the FCgammaRI, FCgammaRII and FCgammaRIII receptors expression and 
      upregulation by anti-Ro and anti-La on a salivary gland cell line. The present 
      data document that the anti-Ro and anti-La autoantibodies determine an increase 
      of the FcgammaRs expression on salivary gland cells, and provide evidence that 
      both the high affinity FcgammaRI and the low affinity FcgammaRII and FcgammaRIII 
      are overexpressed. Treatment with IgG isolated from healthy donors had no effect 
      on the basal FCgammaRs expression.
FAU - Lisi, Sabrina
AU  - Lisi S
AD  - Department of Human Anatomy and Histology, University of Bari, p.zza G. Cesare 1, 
      70124, Bari, Italy. s.lisi@anatomia.uniba.it
FAU - D'Amore, Massimo
AU  - D'Amore M
FAU - Lofrumento, Dario
AU  - Lofrumento D
FAU - Mitolo, Vincenzo
AU  - Mitolo V
FAU - Frassanito, Maria Antonia
AU  - Frassanito MA
FAU - Dammacco, Francesco
AU  - Dammacco F
FAU - Scagliusi, Pasquale
AU  - Scagliusi P
FAU - Sisto, Margherita
AU  - Sisto M
LA  - eng
PT  - Journal Article
DEP - 20080209
PL  - Germany
TA  - Rheumatol Int
JT  - Rheumatology international
JID - 8206885
RN  - 0 (Antibodies, Antinuclear)
RN  - 0 (Autoantigens)
RN  - 0 (Receptors, IgG)
RN  - 0 (Ribonucleoproteins)
RN  - 0 (SS-A antigen)
SB  - IM
MH  - Antibodies, Antinuclear/*immunology
MH  - Autoantigens/immunology
MH  - Case-Control Studies
MH  - Cell Line
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Receptors, IgG/immunology/*metabolism
MH  - Ribonucleoproteins/immunology
MH  - Salivary Glands/immunology/*metabolism
MH  - Sjogren's Syndrome/*immunology
MH  - Up-Regulation
MH  - SS-B Antigen
EDAT- 2008/02/12 09:00
MHDA- 2009/01/28 09:00
CRDT- 2008/02/12 09:00
PHST- 2007/07/10 00:00 [received]
PHST- 2008/01/14 00:00 [accepted]
PHST- 2008/02/12 09:00 [pubmed]
PHST- 2009/01/28 09:00 [medline]
PHST- 2008/02/12 09:00 [entrez]
AID - 10.1007/s00296-008-0536-5 [doi]
PST - ppublish
SO  - Rheumatol Int. 2008 Jul;28(9):943-8. doi: 10.1007/s00296-008-0536-5. Epub 2008 
      Feb 9.