PMID- 18264994
OWN - NLM
STAT- MEDLINE
DCOM- 20080617
LR  - 20211020
IS  - 1932-8451 (Print)
IS  - 1932-846X (Electronic)
IS  - 1932-8451 (Linking)
VI  - 68
IP  - 5
DP  - 2008 Apr
TI  - Stress experienced in utero reduces sexual dichotomies in neurogenesis, 
      microenvironment, and cell death in the adult rat hippocampus.
PG  - 575-89
LID - 10.1002/dneu.20600 [doi]
AB  - Hippocampal function and plasticity differ with gender, but the regulatory 
      mechanisms underlying sex differences remain elusive and may be established early 
      in life. The present study sought to elucidate sex differences in hippocampal 
      plasticity under normal developmental conditions and in response to repetitive, 
      predictable versus varied, unpredictable prenatal stress (PS). Adult male and 
      diestrous female offspring of pregnant rats exposed to no stress (control), 
      repetitive stress (PS-restraint), or a randomized sequence of varied stressors 
      (PS-random) during the last week of pregnancy were examined for hippocampal 
      proliferation, neurogenesis, cell death, and local microenvironment using 
      endogenous markers. Regional volume was also estimated by stereology. Control 
      animals had comparable proliferation and regional volume regardless of sex, but 
      females had lower neurogenesis compared to males. Increased cell death and 
      differential hippocampal precursor kinetics both appear to contribute to reduced 
      neurogenesis in females. Reduced local interleukin-1beta (IL-1beta) 
      immunoreactivity (IR) in females argues for a mechanistic role for the 
      anti-apoptotic cytokine in driving sex differences in cell death. Prenatal stress 
      significantly impacted the hippocampus, with both stress paradigms causing robust 
      decreases in actively proliferating cells in males and females. Several other 
      hippocampal measures were feminized in males such as precursor kinetics, 
      IL-1beta-IR density, and cell death, reducing or abolishing some sex differences. 
      The findings expand our understanding of the mechanisms underlying sex 
      differences and highlight the critical role early stress can play on the balance 
      between proliferation, neurogenesis, cell death, and hippocampal microenvironment 
      in adulthood.
FAU - Mandyam, Chitra D
AU  - Mandyam CD
AD  - Committee on the Neurobiology of Addictive Disorders, The Scripps Research 
      Institute, La Jolla, California, USA. cmandyam@scripps.edu
FAU - Crawford, Elena F
AU  - Crawford EF
FAU - Eisch, Amelia J
AU  - Eisch AJ
FAU - Rivier, Catherine L
AU  - Rivier CL
FAU - Richardson, Heather N
AU  - Richardson HN
LA  - eng
GR  - MH51774/MH/NIMH NIH HHS/United States
GR  - R01 DA010072/DA/NIDA NIH HHS/United States
GR  - K01 DA022473/DA/NIDA NIH HHS/United States
GR  - DA022473/DA/NIDA NIH HHS/United States
GR  - DA010072/DA/NIDA NIH HHS/United States
GR  - P60 AA006420/AA/NIAAA NIH HHS/United States
GR  - R01 MH051774/MH/NIMH NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - Dev Neurobiol
JT  - Developmental neurobiology
JID - 101300215
RN  - 0 (Interleukin-1beta)
SB  - IM
MH  - Animals
MH  - Cell Count
MH  - Cell Death/physiology
MH  - Data Interpretation, Statistical
MH  - Dentate Gyrus/pathology/physiopathology
MH  - Environment
MH  - Female
MH  - Feminization/physiopathology
MH  - Hippocampus/cytology/*physiology
MH  - Immunohistochemistry
MH  - Interleukin-1beta/metabolism
MH  - Male
MH  - Nervous System/*growth & development
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Sex Characteristics
MH  - Stress, Psychological/*physiopathology
PMC - PMC3679899
MID - NIHMS356169
EDAT- 2008/02/12 09:00
MHDA- 2008/06/18 09:00
PMCR- 2013/06/12
CRDT- 2008/02/12 09:00
PHST- 2008/02/12 09:00 [pubmed]
PHST- 2008/06/18 09:00 [medline]
PHST- 2008/02/12 09:00 [entrez]
PHST- 2013/06/12 00:00 [pmc-release]
AID - 10.1002/dneu.20600 [doi]
PST - ppublish
SO  - Dev Neurobiol. 2008 Apr;68(5):575-89. doi: 10.1002/dneu.20600.