PMID- 18266897
OWN - NLM
STAT- MEDLINE
DCOM- 20080415
LR  - 20151119
IS  - 1398-9995 (Electronic)
IS  - 0105-4538 (Linking)
VI  - 63
IP  - 4
DP  - 2008 Apr
TI  - Modulation of neurotrophin and neurotrophin receptor expression in nasal mucosa 
      after nasal allergen provocation in allergic rhinitis.
PG  - 468-75
LID - 10.1111/j.1398-9995.2008.01626.x [doi]
AB  - BACKGROUND: Patients with allergic rhinitis (AR) feature both allergic airway 
      inflammation and a hyperresponsiveness to nonspecific stimuli which is partly 
      neuronally controlled. Still, it is unclear whether or not neurotrophins are 
      involved in airway pathophysiology of AR and in nasobronchial interaction. 
      METHODS: Nine AR patients with mono-allergy to grass pollen and nine healthy 
      controls underwent nasal allergen provocation (NP). Serum samples, nasal and 
      bronchial biopsies were taken before (T(0)) and 24 h after (T(24)) NP. 
      Pan-neurotrophin receptor p75(NTR), tyrosine kinase A (trkA), trkB, nerve growth 
      factor (NGF), and brain-derived neurotrophic factor (BDNF) were assessed with 
      immunohistochemistry, and NGF and BDNF levels with ELISA. RESULTS: At T(24), BDNF 
      and NGF were upregulated in nasal mucosa (P < 0.05) and increased in the 
      peripheral blood of AR compared with T(0). The increase in nasal BDNF expression 
      correlated positively with the maximum increase in total nasal symptom score in 
      AR (P = 0.02). p75(NTR) was expressed on peripheral nerves and epithelial layer, 
      trkA on endothelial cells, and trkB on mast cells. trkB + mast cells 
      significantly decreased after NP in AR (P < 0.01). NP did not modulate p75(NTR) 
      and trkA expression in nasal mucosa and had no effect on the expression of 
      neurotrophins and receptors in bronchial mucosa. CONCLUSION: This study shows 
      that neurotrophins and their receptors are expressed in human airways. Allergic 
      rhinitis was characterized by a modulation of BDNF, NGF, and trkB in nasal mucosa 
      after NP and a correlation of nasal BDNF with the maximal increase of total nasal 
      symptom score. Therefore, our data suggest that neurotrophins participate in 
      upper-airway pathophysiology in AR, whereas their role in nasobronchial 
      interaction remains unclear.
FAU - Raap, U
AU  - Raap U
AD  - Department of Dermatology and Allergology, Hannover Medical University, Hannover, 
      Germany.
FAU - Fokkens, W
AU  - Fokkens W
FAU - Bruder, M
AU  - Bruder M
FAU - Hoogsteden, H
AU  - Hoogsteden H
FAU - Kapp, A
AU  - Kapp A
FAU - Braunstahl, G-J
AU  - Braunstahl GJ
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080211
PL  - Denmark
TA  - Allergy
JT  - Allergy
JID - 7804028
RN  - 0 (Allergens)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Receptor, Nerve Growth Factor)
RN  - 9061-61-4 (Nerve Growth Factor)
RN  - EC 2.7.10.1 (Receptor, trkA)
RN  - EC 2.7.10.1 (Receptor, trkB)
SB  - IM
MH  - Adult
MH  - Allergens
MH  - Brain-Derived Neurotrophic Factor/blood/*immunology
MH  - Bronchi/immunology
MH  - Female
MH  - Humans
MH  - Male
MH  - Mast Cells/immunology
MH  - Nasal Cavity/immunology
MH  - Nasal Provocation Tests
MH  - Nerve Growth Factor/blood/*immunology
MH  - Poaceae/immunology
MH  - Pollen/immunology
MH  - Receptor, Nerve Growth Factor/*immunology
MH  - Receptor, trkA/*immunology
MH  - Receptor, trkB/*immunology
MH  - Respiratory Mucosa/*immunology
MH  - Rhinitis, Allergic, Seasonal/blood/*immunology
EDAT- 2008/02/13 09:00
MHDA- 2008/04/16 09:00
CRDT- 2008/02/13 09:00
PHST- 2008/02/13 09:00 [pubmed]
PHST- 2008/04/16 09:00 [medline]
PHST- 2008/02/13 09:00 [entrez]
AID - ALL1626 [pii]
AID - 10.1111/j.1398-9995.2008.01626.x [doi]
PST - ppublish
SO  - Allergy. 2008 Apr;63(4):468-75. doi: 10.1111/j.1398-9995.2008.01626.x. Epub 2008 
      Feb 11.