PMID- 18268352
OWN - NLM
STAT- MEDLINE
DCOM- 20080313
LR  - 20220408
IS  - 1091-6490 (Electronic)
IS  - 0027-8424 (Print)
IS  - 0027-8424 (Linking)
VI  - 105
IP  - 7
DP  - 2008 Feb 19
TI  - Lifespan and reproduction in Drosophila: New insights from nutritional geometry.
PG  - 2498-503
LID - 10.1073/pnas.0710787105 [doi]
AB  - Modest dietary restriction (DR) prolongs life in a wide range of organisms, 
      spanning single-celled yeast to mammals. Here, we report the use of recent 
      techniques in nutrition research to quantify the detailed relationship between 
      diet, nutrient intake, lifespan, and reproduction in Drosophila melanogaster. 
      Caloric restriction (CR) was not responsible for extending lifespan in our 
      experimental flies. Response surfaces for lifespan and fecundity were maximized 
      at different protein-carbohydrate intakes, with longevity highest at a 
      protein-to-carbohydrate ratio of 1:16 and egg-laying rate maximized at 1:2. 
      Lifetime egg production, the measure closest to fitness, was maximized at an 
      intermediate P:C ratio of 1:4. Flies offered a choice of complementary foods 
      regulated intake to maximize lifetime egg production. The results indicate a role 
      for both direct costs of reproduction and other deleterious consequences of 
      ingesting high levels of protein. We unite a body of apparently conflicting work 
      within a common framework and provide a platform for studying aging in all 
      organisms.
FAU - Lee, Kwang Pum
AU  - Lee KP
AD  - School of Biological Sciences and Centre for Mathematical Biology, University of 
      Sydney, Sydney NSW 2006, Australia.
FAU - Simpson, Stephen J
AU  - Simpson SJ
FAU - Clissold, Fiona J
AU  - Clissold FJ
FAU - Brooks, Robert
AU  - Brooks R
FAU - Ballard, J William O
AU  - Ballard JW
FAU - Taylor, Phil W
AU  - Taylor PW
FAU - Soran, Nazaneen
AU  - Soran N
FAU - Raubenheimer, David
AU  - Raubenheimer D
LA  - eng
GR  - R01 GM067862/GM/NIGMS NIH HHS/United States
GR  - R01 GM067862-01/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20080211
PL  - United States
TA  - Proc Natl Acad Sci U S A
JT  - Proceedings of the National Academy of Sciences of the United States of America
JID - 7505876
RN  - 0 (Carbohydrates)
RN  - 0 (Proteins)
SB  - IM
MH  - Animals
MH  - *Caloric Restriction
MH  - Carbohydrates
MH  - Drosophila melanogaster/*physiology
MH  - Longevity/*physiology
MH  - Proteins
PMC - PMC2268165
COIS- The authors declare no conflict of interest.
EDAT- 2008/02/13 09:00
MHDA- 2008/03/14 09:00
PMCR- 2008/08/19
CRDT- 2008/02/13 09:00
PHST- 2008/02/13 09:00 [pubmed]
PHST- 2008/03/14 09:00 [medline]
PHST- 2008/02/13 09:00 [entrez]
PHST- 2008/08/19 00:00 [pmc-release]
AID - 0710787105 [pii]
AID - 9381 [pii]
AID - 10.1073/pnas.0710787105 [doi]
PST - ppublish
SO  - Proc Natl Acad Sci U S A. 2008 Feb 19;105(7):2498-503. doi: 
      10.1073/pnas.0710787105. Epub 2008 Feb 11.