PMID- 18269660
OWN - NLM
STAT- MEDLINE
DCOM- 20080318
LR  - 20220409
IS  - 1600-051X (Electronic)
IS  - 0303-6979 (Linking)
VI  - 35
IP  - 3
DP  - 2008 Mar
TI  - Characterization of progressive periodontal lesions in chronic periodontitis 
      patients: levels of chemokines, cytokines, matrix metalloproteinase-13, 
      periodontal pathogens and inflammatory cells.
PG  - 206-14
LID - 10.1111/j.1600-051X.2007.01190.x [doi]
AB  - BACKGROUND AND AIMS: Periodontitis is an infection with an episodic nature of 
      tissue support destruction. The aim of this work was to determine the levels of 
      chemokines, cytokines, matrix metalloproteinase-13, periodontal pathogens and 
      inflammatory cells in periodontal sites characterized by active periodontal 
      connective tissue destruction. MATERIAL AND METHOD: Fifty-six patients with 
      moderate or advanced severity of chronic periodontitis were selected. 
      Periodontitis was characterized by at least six sites with probing depth > or =5 
      mm, clinical attachment level > or =3 mm and radiographic bone loss. 
      Periodontitis progression was determined by the tolerance method. Receptor 
      activator for nuclear factor kappa B-ligand (RANK-L), monocyte chemoattractant 
      protein-1 (MCP-1), tumour necrosis factor-alpha (TNF-alpha), IL-1beta, MMP-13, 
      Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis, Tannerella 
      forsithia and inflammatory cells levels were determined. Statistical analysis was 
      performed using the Stata 7.0 software. Data were expressed as mean+/-SD and 
      paired samples t-test and chi(2) tests were used. RESULTS: Higher RANK-L, 
      IL-1beta and MMP-13 activity levels were observed in active sites (p<0.05). The 
      proportion of P. gingivalis, A. actinomycetemcomitans, T. forsythia and the 
      number of CD4(+) T were higher in active than in inactive sites (p>0.05). 
      CONCLUSION: The detection of periodontopathic bacteria, host matrix 
      metalloproteinases and cytokines in periodontitis patients with lesions 
      undergoing episodic attachment loss could partially explain the mechanisms 
      associated with the destruction of the supporting tissues of the tooth.
FAU - Silva, Nora
AU  - Silva N
AD  - Area de Microbiologia, Dentistry School, University of Chile, Santiago, Chile.
FAU - Dutzan, Nicolas
AU  - Dutzan N
FAU - Hernandez, Marcela
AU  - Hernandez M
FAU - Dezerega, Andrea
AU  - Dezerega A
FAU - Rivera, Oriana
AU  - Rivera O
FAU - Aguillon, Juan Carlos
AU  - Aguillon JC
FAU - Aravena, Octavio
AU  - Aravena O
FAU - Lastres, Pedro
AU  - Lastres P
FAU - Pozo, Patricia
AU  - Pozo P
FAU - Vernal, Rolando
AU  - Vernal R
FAU - Gamonal, Jorge
AU  - Gamonal J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Clin Periodontol
JT  - Journal of clinical periodontology
JID - 0425123
RN  - 0 (Chemokine CCL2)
RN  - 0 (Chemokines)
RN  - 0 (Cytokines)
RN  - 0 (Interleukin-1beta)
RN  - 0 (Peptide Fragments)
RN  - 0 (RANK Ligand)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 0 (monocyte chemoattractant protein 1 (66-77))
RN  - EC 3.4.24.- (Matrix Metalloproteinase 13)
SB  - IM
MH  - Adult
MH  - Chemokine CCL2/analysis
MH  - Chemokines/*analysis
MH  - Chronic Disease
MH  - Cytokines/*analysis
MH  - Dental Plaque/microbiology
MH  - Epidemiologic Methods
MH  - Female
MH  - Gingiva/cytology/surgery
MH  - Gingival Crevicular Fluid/*chemistry/enzymology
MH  - Humans
MH  - Interleukin-1beta/analysis
MH  - Male
MH  - Matrix Metalloproteinase 13/*analysis
MH  - Middle Aged
MH  - Peptide Fragments/analysis
MH  - *Periodontitis/diagnostic imaging/enzymology/microbiology
MH  - RANK Ligand/analysis
MH  - Radiography
MH  - Tumor Necrosis Factor-alpha/analysis
EDAT- 2008/02/14 09:00
MHDA- 2008/03/19 09:00
CRDT- 2008/02/14 09:00
PHST- 2008/02/14 09:00 [pubmed]
PHST- 2008/03/19 09:00 [medline]
PHST- 2008/02/14 09:00 [entrez]
AID - CPE1190 [pii]
AID - 10.1111/j.1600-051X.2007.01190.x [doi]
PST - ppublish
SO  - J Clin Periodontol. 2008 Mar;35(3):206-14. doi: 10.1111/j.1600-051X.2007.01190.x.