PMID- 18270817
OWN - NLM
STAT- MEDLINE
DCOM- 20080820
LR  - 20220330
IS  - 0364-3190 (Print)
IS  - 0364-3190 (Linking)
VI  - 33
IP  - 7
DP  - 2008 Jul
TI  - Plasma concentrations of brain-derived neurotrophic factor in patients undergoing 
      minor surgery: a randomized controlled trial.
PG  - 1325-31
LID - 10.1007/s11064-007-9586-4 [doi]
AB  - We measured perioperative plasma concentrations of brain-derived neurotrophic 
      factor (BDNF), a major mediator of synaptic plasticity in the central nervous 
      system, in males, 30-65 years old, undergoing lumbar or cervical discotomy. 
      Patients were randomly allocated to a general anesthetic with propofol induction 
      and maintenance or with thiopental induction and isoflurane maintenance. BDNF 
      plasma concentrations were measured before induction (baseline), 15 min after 
      induction but before start of surgery, at skin closure, in the post-anesthetic 
      care unit, and 24 h postoperatively. Data from 26 patients (13 in each group) 
      were analyzed. At each time point, BDNF plasma concentrations showed large 
      variability. At baseline, concentrations were 631 +/- 337 (mean +/- SD) pg ml(-1) 
      in the propofol group and were 549 +/- 512 pg ml(-1) in the thiopental-isoflurane 
      group (P = 0.31). At 15 min, concentrations significantly decreased in the 
      propofol group (247 +/- 219 pg ml(-1), P = 0.0012 compared with baseline) but 
      remained unchanged in the thiopental-isoflurane group (597 +/- 471 pg ml(-1), P = 
      0.798 compared with baseline). At skin closure and in the post-anesthetic care 
      unit, concentrations were not different from baseline in both groups. At 24 h, 
      concentrations significantly decreased below baseline in both groups (propofol: 
      232 +/- 129 pg ml(-1), P = 0.0015; thiopental-isoflurane: 253 +/- 250 pg ml(-1), 
      P = 0.016). In the propofol group, there was a weak but statistically significant 
      positive correlation (R2 = 0.38, P = 0.026) between the duration of surgery and 
      BDNF plasma concentrations at skin closure. These data suggest that in males 
      undergoing elective minor surgery, BDNF plasma concentrations show a specific 
      pattern that is influenced by the anesthetic technique and, possibly, by the 
      duration of surgery.
FAU - Vutskits, Laszlo
AU  - Vutskits L
AD  - Division of Anesthesiology, University Hospitals of Geneva, 24, rue 
      Micheli-du-Crest, CH-1211, Geneva 14, Switzerland. laszlo.vutskits@hcuge.ch
FAU - Lysakowski, Christopher
AU  - Lysakowski C
FAU - Czarnetzki, Christoph
AU  - Czarnetzki C
FAU - Jenny, Benoit
AU  - Jenny B
FAU - Copin, Jean-Christophe
AU  - Copin JC
FAU - Tramer, Martin R
AU  - Tramer MR
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20080213
PL  - United States
TA  - Neurochem Res
JT  - Neurochemical research
JID - 7613461
RN  - 0 (Anesthetics, Inhalation)
RN  - 0 (Anesthetics, Intravenous)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Hypnotics and Sedatives)
RN  - CYS9AKD70P (Isoflurane)
RN  - JI8Z5M7NA3 (Thiopental)
RN  - YI7VU623SF (Propofol)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aging
MH  - Anesthesia, General
MH  - Anesthesia, Intravenous
MH  - Anesthetics, Inhalation
MH  - Anesthetics, Intravenous
MH  - Body Mass Index
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Diskectomy
MH  - Humans
MH  - Hypnotics and Sedatives
MH  - Isoflurane
MH  - Male
MH  - Middle Aged
MH  - Postoperative Period
MH  - Propofol
MH  - *Surgical Procedures, Operative
MH  - Thiopental
EDAT- 2008/02/14 09:00
MHDA- 2008/08/21 09:00
CRDT- 2008/02/14 09:00
PHST- 2007/10/22 00:00 [received]
PHST- 2007/12/27 00:00 [accepted]
PHST- 2008/02/14 09:00 [pubmed]
PHST- 2008/08/21 09:00 [medline]
PHST- 2008/02/14 09:00 [entrez]
AID - 10.1007/s11064-007-9586-4 [doi]
PST - ppublish
SO  - Neurochem Res. 2008 Jul;33(7):1325-31. doi: 10.1007/s11064-007-9586-4. Epub 2008 
      Feb 13.