PMID- 18272007
OWN - NLM
STAT- MEDLINE
DCOM- 20080325
LR  - 20240117
IS  - 1532-429X (Electronic)
IS  - 1097-6647 (Print)
IS  - 1097-6647 (Linking)
VI  - 10
IP  - 1
DP  - 2008 Jan 24
TI  - Assessment of myocardial infarction in mice by late gadolinium enhancement MR 
      imaging using an inversion recovery pulse sequence at 9.4T.
PG  - 6
LID - 10.1186/1532-429X-10-6 [doi]
AB  - PURPOSE: To demonstrate the feasibility of using an inversion recovery pulse 
      sequence and to define the optimal inversion time (TI) to assess myocardial 
      infarction in mice by late gadolinium enhancement (LGE) MRI at 9.4T, and to 
      obtain the maximal contrast between the infarcted and the viable myocardium. 
      METHODS: MRI was performed at 9.4T in mice, two days after induction of 
      myocardial infarction (n = 4). For cardiovascular MR imaging, a segmented 
      magnetization-prepared fast low angle shot (MP-FLASH) sequence was used with 
      varied TIs ranging from 40 to 420 ms following administration of gadolinium-DTPA 
      at 0.6 mmol/kg. Contrast-to-noise (CNR) and signal-to-noise ratio (SNR) were 
      measured and compared for each myocardial region of interest (ROI). RESULTS: The 
      optimal TI, which corresponded to a minimum SNR in the normal myocardium, was 268 
      ms +/- 27.3. The SNR in the viable myocardium was significantly different from 
      that found in the infarcted myocardium (17.2 +/- 2.4 vs 82.1 +/- 10.8; p = 0.006) 
      leading to a maximal relative SI (Signal Intensity) between those two areas 
      (344.9 +/- 60.4). CONCLUSION: Despite the rapid heart rate in mice, our study 
      demonstrates that LGE MRI can be performed at 9.4T using a protocol similar to 
      the one used for clinical MR diagnosis of myocardial infarction.
FAU - Chapon, Catherine
AU  - Chapon C
AD  - Stem Cell Imaging, MRC Clinical Sciences Centre, Hammersmith Hospital, Imperial 
      College London, UK. catherine.chapon@univ-angers.fr
FAU - Herlihy, Amy H
AU  - Herlihy AH
FAU - Bhakoo, Kishore K
AU  - Bhakoo KK
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080124
PL  - England
TA  - J Cardiovasc Magn Reson
JT  - Journal of cardiovascular magnetic resonance : official journal of the Society 
      for Cardiovascular Magnetic Resonance
JID - 9815616
RN  - 0 (Contrast Media)
RN  - K2I13DR72L (Gadolinium DTPA)
SB  - IM
MH  - Analysis of Variance
MH  - Animals
MH  - Contrast Media
MH  - Disease Models, Animal
MH  - Feasibility Studies
MH  - Gadolinium DTPA
MH  - Heart Rate
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Myocardial Infarction/*diagnosis
PMC - PMC2244610
EDAT- 2008/02/15 09:00
MHDA- 2008/03/26 09:00
PMCR- 2008/01/24
CRDT- 2008/02/15 09:00
PHST- 2007/12/20 00:00 [received]
PHST- 2008/01/24 00:00 [accepted]
PHST- 2008/02/15 09:00 [pubmed]
PHST- 2008/03/26 09:00 [medline]
PHST- 2008/02/15 09:00 [entrez]
PHST- 2008/01/24 00:00 [pmc-release]
AID - S1097-6647(23)01223-1 [pii]
AID - 1532-429X-10-6 [pii]
AID - 10.1186/1532-429X-10-6 [doi]
PST - epublish
SO  - J Cardiovasc Magn Reson. 2008 Jan 24;10(1):6. doi: 10.1186/1532-429X-10-6.