PMID- 18272816
OWN - NLM
STAT- MEDLINE
DCOM- 20080715
LR  - 20220310
IS  - 1528-0020 (Electronic)
IS  - 0006-4971 (Print)
IS  - 0006-4971 (Linking)
VI  - 111
IP  - 12
DP  - 2008 Jun 15
TI  - Clonally related follicular lymphomas and histiocytic/dendritic cell sarcomas: 
      evidence for transdifferentiation of the follicular lymphoma clone.
PG  - 5433-9
LID - 10.1182/blood-2007-11-124792 [doi]
AB  - Rare cases of histiocytic and dendritic cell (H/DC) neoplasms have been reported 
      in patients with follicular lymphoma (FL), but the biologic relationship between 
      the 2 neoplasms is unknown. We studied 8 patients with both FL and H/DC neoplasms 
      using immunohistochemistry, fluorescence in situ hybridization (FISH) for 
      t(14;18), and polymerase chain reaction (PCR)/sequencing of BCL2 and IGH 
      rearrangements. There were 5 men and 3 women (median age, 59 years). All cases of 
      FL were positive for t(14;18). The H/DC tumors included 7 histiocytic sarcomas, 5 
      of which showed evidence of dendritic differentiation, and 1 interdigitating cell 
      sarcoma. Five H/DC tumors were metachronous, following FL by 2 months to 12 
      years; tumors were synchronous in 3. All 8 H/DC tumors showed presence of the 
      t(14;18) either by FISH, or in 2 cases by PCR with the major breakpoint region 
      (MBR) probe. PCR and sequencing identified identical IGH gene rearrangements or 
      BCL2 gene breakpoints in all patients tested. All H/DC tumors lacked PAX5, and 
      up-regulation of CEBPbeta and PU.1 was seen in all cases tested. These results 
      provide evidence for a common clonal origin of FL and H/DC neoplasms when 
      occurring in the same patient, and suggest that lineage plasticity may occur in 
      mature lymphoid neoplasms.
FAU - Feldman, Andrew L
AU  - Feldman AL
AD  - Laboratory of Pathology, National Cancer Institute, Bethesda, MD 20892-1500, USA.
FAU - Arber, Daniel A
AU  - Arber DA
FAU - Pittaluga, Stefania
AU  - Pittaluga S
FAU - Martinez, Antonio
AU  - Martinez A
FAU - Burke, Jerome S
AU  - Burke JS
FAU - Raffeld, Mark
AU  - Raffeld M
FAU - Camos, Mireia
AU  - Camos M
FAU - Warnke, Roger
AU  - Warnke R
FAU - Jaffe, Elaine S
AU  - Jaffe ES
LA  - eng
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20080213
PL  - United States
TA  - Blood
JT  - Blood
JID - 7603509
SB  - IM
CIN - Blood. 2008 Jun 15;111(12):5418-9. PMID: 18544687
MH  - Adult
MH  - Aged
MH  - Cell Differentiation
MH  - Cell Lineage
MH  - Cell Transdifferentiation
MH  - Dendritic Cell Sarcoma, Follicular/*genetics/*pathology
MH  - Dendritic Cells, Follicular/pathology/physiology
MH  - Female
MH  - Gene Expression Regulation, Neoplastic
MH  - Gene Rearrangement
MH  - Histiocytic Sarcoma/*genetics/*pathology
MH  - Humans
MH  - Immunohistochemistry
MH  - Immunophenotyping
MH  - In Situ Hybridization, Fluorescence
MH  - Lymphoma, Follicular/*genetics/*pathology
MH  - Male
MH  - Middle Aged
MH  - Neoplasms, Second Primary/genetics/pathology
MH  - Polymerase Chain Reaction
PMC - PMC2424145
EDAT- 2008/02/15 09:00
MHDA- 2008/07/17 09:00
PMCR- 2009/06/15
CRDT- 2008/02/15 09:00
PHST- 2008/02/15 09:00 [pubmed]
PHST- 2008/07/17 09:00 [medline]
PHST- 2008/02/15 09:00 [entrez]
PHST- 2009/06/15 00:00 [pmc-release]
AID - S0006-4971(20)47076-4 [pii]
AID - 2007/124792 [pii]
AID - 10.1182/blood-2007-11-124792 [doi]
PST - ppublish
SO  - Blood. 2008 Jun 15;111(12):5433-9. doi: 10.1182/blood-2007-11-124792. Epub 2008 
      Feb 13.