PMID- 18272866
OWN - NLM
STAT- MEDLINE
DCOM- 20080619
LR  - 20220321
IS  - 1526-632X (Electronic)
IS  - 0028-3878 (Linking)
VI  - 70
IP  - 13 Pt 2
DP  - 2008 Mar 25
TI  - Integrating risk factors: HLA-DRB1*1501 and Epstein-Barr virus in multiple 
      sclerosis.
PG  - 1113-8
LID - 10.1212/01.wnl.0000294325.63006.f8 [doi]
AB  - BACKGROUND: Individuals with high levels of antibodies to the Epstein-Barr virus 
      nuclear antigen 1 (EBNA-1) have an increased risk of developing multiple 
      sclerosis (MS), but this association could be confounded by genetic 
      susceptibility. METHODS: We conducted a nested case-control study including 148 
      women with MS (18 with blood collected before disease onset) and 296 age-matched 
      healthy women to determine whether the human leukocyte antigen (HLA) DRB1*1501 
      allele (DR15) and anti-Epstein-Barr virus (anti-EBV) antibody titers are 
      independent risk factors for MS. RESULTS: The association between anti-EBNA-1 
      antibody titers and MS risk was not affected by adjustment for DR15 and was 
      similar in DR15-positive and DR15-negative women. The relative risk of MS among 
      DR15-positive women with elevated (>1:320) anti-EBNA-1 titers was ninefold higher 
      than that of DR15-negative women with low (<1:80) anti-EBNA-1 titers. 
      CONCLUSIONS: Anti-Epstein-Barr virus nuclear antigen 1 (anti-EBNA-1) antibody 
      titers are a risk factor for multiple sclerosis (MS), independently from the DR15 
      allele. Carriers of the DR15 allele with elevated anti-EBNA-1 antibody titers may 
      have a markedly increased risk of MS.
FAU - De Jager, P L
AU  - De Jager PL
AD  - Center for Neurologic Diseases, Department of Neurology, Brigham and Women's 
      Hospital and Harvard Medical School, Boston, MA, USA.
FAU - Simon, K C
AU  - Simon KC
FAU - Munger, K L
AU  - Munger KL
FAU - Rioux, J D
AU  - Rioux JD
FAU - Hafler, D A
AU  - Hafler DA
FAU - Ascherio, A
AU  - Ascherio A
LA  - eng
GR  - K08 NS046341/NS/NINDS NIH HHS/United States
GR  - R01 NS47467/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20080213
PL  - United States
TA  - Neurology
JT  - Neurology
JID - 0401060
RN  - 0 (Antibodies)
RN  - 0 (Biomarkers)
RN  - 0 (Epstein-Barr Virus Nuclear Antigens)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - O5GA75RST7 (EBV-encoded nuclear antigen 1)
SB  - IM
CIN - Neurology. 2008 Mar 25;70(13 Pt 2):1067-8. PMID: 18362267
MH  - Adult
MH  - Antibodies/analysis/blood/immunology
MH  - Biomarkers/analysis/blood
MH  - Case-Control Studies
MH  - Comorbidity
MH  - Epstein-Barr Virus Infections/*epidemiology/genetics/*immunology
MH  - Epstein-Barr Virus Nuclear Antigens/immunology
MH  - Female
MH  - Gene Frequency/genetics/immunology
MH  - Genetic Predisposition to Disease/epidemiology
MH  - Genotype
MH  - HLA-DR Antigens/*blood/genetics/*immunology
MH  - HLA-DRB1 Chains
MH  - Herpesvirus 4, Human/immunology
MH  - Heterozygote
MH  - Humans
MH  - Middle Aged
MH  - Multiple Sclerosis/*epidemiology/genetics/*immunology
MH  - Risk Factors
EDAT- 2008/02/15 09:00
MHDA- 2008/06/20 09:00
CRDT- 2008/02/15 09:00
PHST- 2008/02/15 09:00 [pubmed]
PHST- 2008/06/20 09:00 [medline]
PHST- 2008/02/15 09:00 [entrez]
AID - 01.wnl.0000294325.63006.f8 [pii]
AID - 10.1212/01.wnl.0000294325.63006.f8 [doi]
PST - ppublish
SO  - Neurology. 2008 Mar 25;70(13 Pt 2):1113-8. doi: 
      10.1212/01.wnl.0000294325.63006.f8. Epub 2008 Feb 13.