PMID- 18274642
OWN - NLM
STAT- MEDLINE
DCOM- 20080523
LR  - 20211020
IS  - 1466-1861 (Electronic)
IS  - 0962-9351 (Print)
IS  - 0962-9351 (Linking)
VI  - 2007
DP  - 2007
TI  - Perinatal plasma monocyte chemotactic protein-1 concentrations in intrauterine 
      growth restriction.
PG  - 65032
LID - 10.1155/2007/65032 [doi]
LID - 65032
AB  - Monocyte-chemotactic-protein-1 (MCP-1) plays vital roles in immune response, 
      angiogenesis, and pregnancy outcome. We investigated plasma MCP-1 concentrations 
      in 40 mothers and their 20 intrauterine-growth-restricted (IUGR) and 20 
      appropriate-for-gestational-age (AGA) fetuses and neonates on postnatal days 1 
      (N1) and 4 (N4). Maternal and fetal MCP-1 concentrations were decreased (P<001 
      and P = .018, resp.), whereas N1 MCP-1 concentrations were elevated in IUGR group 
      (P = .012). In both groups, fetal MCP-1 concentrations were lower compared to N1 
      and N4 ones (P = .045, P = .012, resp., for AGA, P< .001 in each case for IUGR). 
      Reduced maternal and fetal MCP-1 concentrations in IUGR may reflect failure of 
      trophoblast invasion, suggesting that down-regulation of MCP-1 may be involved in 
      the pathogenesis of IUGR. Increased MCP-1 concentrations in IUGR neonates and 
      higher postnatal ones in all infants may be attributed to gradual initiation of 
      ex utero angiogenesis, which is possibly enhanced in IUGR.
FAU - Briana, Despina D
AU  - Briana DD
AD  - Second Department of Obstetrics and Gynecology, Athens University Medical School, 
      11528 Athens, Greece.
FAU - Boutsikou, Maria
AU  - Boutsikou M
FAU - Baka, Stavroula
AU  - Baka S
FAU - Papadopoulos, George
AU  - Papadopoulos G
FAU - Gourgiotis, Dimitrios
AU  - Gourgiotis D
FAU - Puchner, Karl Philipp
AU  - Puchner KP
FAU - Hassiakos, Dimitrios
AU  - Hassiakos D
FAU - Malamitsi-Puchner, Ariadne
AU  - Malamitsi-Puchner A
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Mediators Inflamm
JT  - Mediators of inflammation
JID - 9209001
RN  - 0 (Chemokine CCL2)
RN  - 0 (Cytokines)
SB  - IM
MH  - Adult
MH  - Birth Weight
MH  - Chemokine CCL2/*blood
MH  - Cytokines/metabolism
MH  - Female
MH  - Fetal Growth Retardation/*blood/diagnosis
MH  - *Gene Expression Regulation
MH  - Gestational Age
MH  - Humans
MH  - Infant, Newborn
MH  - Male
MH  - Parity
MH  - Pregnancy
MH  - Pregnancy Complications
MH  - Sex Factors
PMC - PMC2234089
EDAT- 2008/02/16 09:00
MHDA- 2008/05/24 09:00
PMCR- 2007/11/18
CRDT- 2008/02/16 09:00
PHST- 2007/07/23 00:00 [received]
PHST- 2007/10/11 00:00 [accepted]
PHST- 2008/02/16 09:00 [pubmed]
PHST- 2008/05/24 09:00 [medline]
PHST- 2008/02/16 09:00 [entrez]
PHST- 2007/11/18 00:00 [pmc-release]
AID - 10.1155/2007/65032 [doi]
PST - ppublish
SO  - Mediators Inflamm. 2007;2007:65032. doi: 10.1155/2007/65032.