PMID- 18274833
OWN - NLM
STAT- MEDLINE
DCOM- 20081022
LR  - 20211020
IS  - 0925-5710 (Print)
IS  - 0925-5710 (Linking)
VI  - 87
IP  - 3
DP  - 2008 Apr
TI  - Close relation between 14q32/IGH translocations and chromosome 13 abnormalities 
      in multiple myeloma: a high incidence of 11q13/CCND1 and 16q23/MAF.
PG  - 260-5
LID - 10.1007/s12185-008-0039-x [doi]
AB  - Many B-cell tumors have chromosomal translocations that result from failures of 
      the immunoglobulin (Ig) gene during V(D)J recombination, somatic hypermutation 
      (SHM), and class switch recombination (CSR). Nearly half of all multiple myeloma 
      (MM) patients have 14q32/IGH translocations in CSR, including the five common 
      translocations of 11q13/CCND1, 6p21/CCND3, 4p16/FGFR3, 16q23/MAF, and 20q11/MAFB. 
      Although 14q32/IGH translocations are closely related to the biological features 
      of MM, the most consistent and powerful prognostic factor has been reported to be 
      the loss of all (monosomy 13/-13) or part of chromosome 13 (del(13)(q14)/13q-). 
      Our fluorescence in situ hybridization (FISH) analysis method was designed to 
      detect -13/13q- and 14q32/IGH rearrangements in 23 MM patients. FISH disclosed 
      14q32/IGH translocations in 10 of the 23 (43.5%) patients. The common 
      translocation partners of 14q32/IGH were 11q13/CCND1 (five patients) and 
      16q23/MAF (four patients), followed in third place by 4p16/FGFR3 (one patient). 
      Nine of the ten patients carrying 14q32/IGH translocations had -13/13q-. 
      Abnormalities of chromosome 13 included -13 in seven (70%) and del(13)(q14) in 
      two (20%). Our results suggest a significant correlation between the presence of 
      14q32/IGH translocations and chromosome 13 abnormalities (P = 0.0276) in MM 
      patients.
FAU - Takimoto, Madoka
AU  - Takimoto M
AD  - Department of Internal Medicine, Division of Hematology and Oncology, St. 
      Marianna University School of Medicine, Kawasaki, Kanagawa, 218-8511, Japan.
FAU - Ogawa, Kohei
AU  - Ogawa K
FAU - Kato, Yo
AU  - Kato Y
FAU - Saito, Tasuku
AU  - Saito T
FAU - Suzuki, Takao
AU  - Suzuki T
FAU - Irei, Michiko
AU  - Irei M
FAU - Shibuya, Yasushi
AU  - Shibuya Y
FAU - Suzuki, Yoshinori
AU  - Suzuki Y
FAU - Kato, Masayuki
AU  - Kato M
FAU - Inoue, Yasuyuki
AU  - Inoue Y
FAU - Takahashi, Masatomo
AU  - Takahashi M
FAU - Sugimori, Hiroki
AU  - Sugimori H
FAU - Miura, Ikuo
AU  - Miura I
LA  - eng
PT  - Journal Article
DEP - 20080216
PL  - Japan
TA  - Int J Hematol
JT  - International journal of hematology
JID - 9111627
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Chromosomes, Human, Pair 13/*genetics
MH  - Cohort Studies
MH  - Female
MH  - Genes, Immunoglobulin Heavy Chain/*genetics
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Middle Aged
MH  - Multiple Myeloma/*genetics
MH  - Translocation, Genetic/*genetics
EDAT- 2008/02/16 09:00
MHDA- 2008/10/23 09:00
CRDT- 2008/02/16 09:00
PHST- 2007/08/22 00:00 [received]
PHST- 2007/11/16 00:00 [accepted]
PHST- 2007/11/04 00:00 [revised]
PHST- 2008/02/16 09:00 [pubmed]
PHST- 2008/10/23 09:00 [medline]
PHST- 2008/02/16 09:00 [entrez]
AID - 10.1007/s12185-008-0039-x [doi]
PST - ppublish
SO  - Int J Hematol. 2008 Apr;87(3):260-5. doi: 10.1007/s12185-008-0039-x. Epub 2008 
      Feb 16.