PMID- 18274996
OWN - NLM
STAT- MEDLINE
DCOM- 20080507
LR  - 20131121
IS  - 0363-0269 (Print)
IS  - 0363-0269 (Linking)
VI  - 32
IP  - 1-2
DP  - 2008
TI  - The effects of bicarbonate and its combination with chelating agents used for the 
      removal of depleted uranium in rats.
PG  - 191-8
LID - 10.1080/03630260701727093 [doi]
AB  - The effects of bicarbonate and its combination with the chelating agents, 
      deferiprone (L1), 4,6-dimethyl-1-hydroxypyrimidin-2(1H)-one (AK-4), 
      catechol-3,6-bis(methyleneimino-diacetic-acid) (CBMIDA), and 
      ethane-1-hydroxy-1,1-bisphoshonate (EHBP) in removing depleted uranium (DU) for 
      radiation emergency medicine were examined. After the intramuscular injection of 
      DU in rats, various time schedules of bicarbonate and chelating agent 
      administration were tested. The results indicate that the bicarbonate helps 
      increase significantly the effects of LI and AK-4, while there were no effects of 
      using bicarbonate alone. The effects of bicarbonate on CBMIDA were unclear, and 
      the effects of EHBP were negative. Further studies are necessary to obtain 
      distinctly synergic effects by the combination of chelating agents with 
      bicarbonate.
FAU - Fukuda, Satoshi
AU  - Fukuda S
AD  - Research Center for Radiation Emergency Medicine, National Institute of 
      Radiological Sciences, Chiba, Japan. s_fukuda@nirs.go.jp
FAU - Ikeda, Mizuyo
AU  - Ikeda M
FAU - Nakamura, Mariko
AU  - Nakamura M
FAU - Katoh, Akira
AU  - Katoh A
FAU - Yan, Xueming
AU  - Yan X
FAU - Xie, Yuyuan
AU  - Xie Y
FAU - Kontoghiorghes, George J
AU  - Kontoghiorghes GJ
LA  - eng
PT  - Journal Article
PL  - England
TA  - Hemoglobin
JT  - Hemoglobin
JID - 7705865
RN  - 0 (Bicarbonates)
RN  - 0 (Chelating Agents)
RN  - 0 (Radiation-Protective Agents)
RN  - 4OC371KSTK (Uranium)
RN  - AYI8EX34EU (Creatinine)
RN  - EC 2.6.1.1 (Aspartate Aminotransferases)
RN  - EC 2.6.1.2 (Alanine Transaminase)
RN  - EC 3.1.3.1 (Alkaline Phosphatase)
RN  - N762921K75 (Nitrogen)
SB  - IM
MH  - Alanine Transaminase/blood/urine
MH  - Alkaline Phosphatase/blood/urine
MH  - Animals
MH  - Aspartate Aminotransferases/blood/urine
MH  - Bicarbonates/metabolism/*therapeutic use
MH  - Chelating Agents/metabolism/*therapeutic use
MH  - Chelation Therapy
MH  - Creatinine/blood/urine
MH  - Male
MH  - Nitrogen/blood/urine
MH  - Radiation Injuries/*drug therapy
MH  - Radiation-Protective Agents/metabolism/therapeutic use
MH  - Rats
MH  - Rats, Wistar
MH  - Uranium/*metabolism
EDAT- 2008/02/16 09:00
MHDA- 2008/05/08 09:00
CRDT- 2008/02/16 09:00
PHST- 2008/02/16 09:00 [pubmed]
PHST- 2008/05/08 09:00 [medline]
PHST- 2008/02/16 09:00 [entrez]
AID - 790612445 [pii]
AID - 10.1080/03630260701727093 [doi]
PST - ppublish
SO  - Hemoglobin. 2008;32(1-2):191-8. doi: 10.1080/03630260701727093.