PMID- 18275850
OWN - NLM
STAT- MEDLINE
DCOM- 20080407
LR  - 20211020
IS  - 1090-2104 (Electronic)
IS  - 0006-291X (Print)
IS  - 0006-291X (Linking)
VI  - 368
IP  - 3
DP  - 2008 Apr 11
TI  - Trim11 increases expression of dopamine beta-hydroxylase gene by interacting with 
      Phox2b.
PG  - 650-5
LID - 10.1016/j.bbrc.2008.01.165 [doi]
AB  - The homeodomain transcription factor Phox2b is one of the key determinants 
      involved in the development of noradrenergic (NA) neurons in both the central 
      nervous system (CNS) and the peripheral nervous system (PNS). Using yeast 
      two-hybrid screening, we isolated a Phox2b interacting protein, Trim11, which 
      belongs to TRIM (Tripartite motif) or RBCC proteins family, and contains a RING 
      domain, B-boxes, a coiled-coil domain, and the B30.2/SPRY domain. Protein-protein 
      interaction assays showed that Phox2b was able to physically interact with 
      Trim11. The B30.2/SPRY domain of Trim11 was required for the interaction with 
      Phox2b. Expression of Phox2b and Trim11 was detected in the sympathetic ganglia 
      (SG) of mouse embryos. Forced expression of Trim11 with Phox2b further increased 
      mRNA levels of dopamine beta-hydroxylase (DBH) gene in primary avian neural crest 
      stem cell (NCSC) culture. This study suggests a potential role for Trim11 in the 
      specification of NA phenotype by interaction with Phox2b.
FAU - Hong, Seok Jong
AU  - Hong SJ
AD  - Molecular Neurobiology Laboratory, McLean Hospital, Harvard Medical School, 115 
      Mill Street, Belmont, MA 02478, USA.
FAU - Chae, Han
AU  - Chae H
FAU - Lardaro, Thomas
AU  - Lardaro T
FAU - Hong, Sunghoi
AU  - Hong S
FAU - Kim, Kwang-Soo
AU  - Kim KS
LA  - eng
GR  - R01 MH048866/MH/NIMH NIH HHS/United States
GR  - R01 MH048866-17/MH/NIMH NIH HHS/United States
GR  - R01 NS084869/NS/NINDS NIH HHS/United States
GR  - R01 DC006501/DC/NIDCD NIH HHS/United States
GR  - R01 DC006501-05/DC/NIDCD NIH HHS/United States
PT  - Journal Article
DEP - 20080212
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Homeodomain Proteins)
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (NBPhox protein)
RN  - 0 (Trans-Activators)
RN  - 0 (Transcription Factors)
RN  - 0 (Trim14 protein, mouse)
RN  - 0 (Tripartite Motif Proteins)
RN  - EC 1.14.17.1 (Dopamine beta-Hydroxylase)
SB  - IM
MH  - Cell Line
MH  - Cells, Cultured
MH  - DNA-Binding Proteins/*metabolism
MH  - Dopamine beta-Hydroxylase/*metabolism
MH  - Ganglia, Sympathetic/*metabolism
MH  - Gene Expression Regulation, Developmental/physiology
MH  - Homeodomain Proteins/*metabolism
MH  - Humans
MH  - Intracellular Signaling Peptides and Proteins
MH  - Kidney/*metabolism
MH  - Neurons/*metabolism
MH  - *Protein Interaction Mapping
MH  - Trans-Activators/*metabolism
MH  - Transcription Factors/*metabolism
MH  - Tripartite Motif Proteins
MH  - Up-Regulation/physiology
PMC - PMC2712928
MID - NIHMS123431
EDAT- 2008/02/16 09:00
MHDA- 2008/04/09 09:00
PMCR- 2009/07/20
CRDT- 2008/02/16 09:00
PHST- 2008/01/23 00:00 [received]
PHST- 2008/01/25 00:00 [accepted]
PHST- 2008/02/16 09:00 [pubmed]
PHST- 2008/04/09 09:00 [medline]
PHST- 2008/02/16 09:00 [entrez]
PHST- 2009/07/20 00:00 [pmc-release]
AID - S0006-291X(08)00189-7 [pii]
AID - 10.1016/j.bbrc.2008.01.165 [doi]
PST - ppublish
SO  - Biochem Biophys Res Commun. 2008 Apr 11;368(3):650-5. doi: 
      10.1016/j.bbrc.2008.01.165. Epub 2008 Feb 12.