PMID- 18277084
OWN - NLM
STAT- MEDLINE
DCOM- 20080321
LR  - 20180614
IS  - 1648-9144 (Electronic)
IS  - 1010-660X (Linking)
VI  - 44
IP  - 1
DP  - 2008
TI  - Natural clearance of hepatitis C virus in hemophilia patients.
PG  - 15-21
AB  - OBJECTIVE: The objective of this study was to investigate the prevalence of HCV 
      (hepatitis C virus) infection in hemophilia patients in Latvia and to analyze 
      association between natural clearance of HCV and human leukocyte antigen (HLA) 
      class II genes. MATERIAL AND METHODS: From 61 hemophilic patients participating 
      in this study, 38 were adults and 23 were pediatric patients younger than 18 
      years. To analyze association between HLA class II alleles and natural clearance 
      of HCV, the gene frequency was compared in hemophilia patients group and the 
      control group of 60 healthy subjects, all men. Serum HCV RNA was qualitatively 
      determined and HLA class II alleles were identified by polymerase chain reaction 
      (PCR) method. RESULTS: HCV infection is common among hemophilia patients in 
      Latvia. Antibodies to HCV were found in 45 of 61 (74%) hemophilia patients. In 
      41% of hemophilia patients (18 of 44), HCV infection resolved spontaneously. 
      Children cleared HCV more frequently than adults (7 of 11 comparing to 11 of 33, 
      respectively; OR=3.50; P<0.05). The frequency difference was found to be 
      statistically significant when comparing HLA alleles distribution in the sample 
      of hemophilia patients who naturally cleared HCV (n=18) and in the control group 
      (n=60) (corresponding frequency of HLA-DRB1*07 allele - 4 (11.11%) and 9 (1.67%); 
      OR=7.38; P<0.05). CONCLUSIONS: Natural clearance of HCV infection is frequently 
      found in hemophilia patients in Latvia. Children are more likely to clear virus 
      naturally than adults. There is an association between natural clearance of HCV 
      and HLA allele DRB1*07 in hemophilia patients.
FAU - Simanis, Raimonds
AU  - Simanis R
AD  - Department of Traditional Infectology, Tuberculosis and AIDS, Riga Stradins 
      University, Latvia. raimonds.simanis@e-teliamtc.lv
FAU - Lejniece, Sandra
AU  - Lejniece S
FAU - Sochnevs, Arturs
AU  - Sochnevs A
FAU - Eglite, Jelena
AU  - Eglite J
FAU - Chernevska, Gunta
AU  - Chernevska G
FAU - Kovalova, Zhanna
AU  - Kovalova Z
FAU - Gardovska, Dace
AU  - Gardovska D
FAU - Jeruma, Agita
AU  - Jeruma A
FAU - Kuse, Velga
AU  - Kuse V
FAU - Viksna, Ludmila
AU  - Viksna L
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Switzerland
TA  - Medicina (Kaunas)
JT  - Medicina (Kaunas, Lithuania)
JID - 9425208
RN  - 0 (HLA Antigens)
RN  - 0 (RNA, Viral)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age Factors
MH  - Chi-Square Distribution
MH  - Child
MH  - Data Interpretation, Statistical
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Genes, MHC Class II
MH  - Genotype
MH  - HLA Antigens/immunology
MH  - Hemophilia A/*complications/genetics/immunology/virology
MH  - Hepacivirus/*genetics/immunology/isolation & purification
MH  - Hepatitis C/*epidemiology/*genetics/immunology
MH  - Humans
MH  - Latvia/epidemiology
MH  - Lithuania
MH  - Male
MH  - Polymerase Chain Reaction
MH  - Prevalence
MH  - RNA, Viral/analysis
MH  - United States
EDAT- 2008/02/16 09:00
MHDA- 2008/03/22 09:00
CRDT- 2008/02/16 09:00
PHST- 2008/02/16 09:00 [pubmed]
PHST- 2008/03/22 09:00 [medline]
PHST- 2008/02/16 09:00 [entrez]
AID - 0801-03e [pii]
PST - ppublish
SO  - Medicina (Kaunas). 2008;44(1):15-21.