PMID- 18278457
OWN - NLM
STAT- MEDLINE
DCOM- 20081117
LR  - 20211020
IS  - 1672-0733 (Print)
IS  - 1672-0733 (Linking)
VI  - 28
IP  - 1
DP  - 2008 Feb
TI  - Changes of high mobility group box 1 in serum of pig acute hepatic failure model 
      and significance.
PG  - 52-5
LID - 10.1007/s11596-008-0113-x [doi]
AB  - The role of the high mobility group box 1 (HMGB-1) in acute hepatic failure and 
      the effect of artificial liver support system treatment on HMGB-1 level were 
      investigated. Pig models of acute hepatic failure were induced by D-galactosamine 
      and randomly divided into two groups with or without artificial liver support 
      system treatment. Tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta 
      (IL-1 beta) levels were detected by the enzyme linked immunosorbent assay 
      (ELISA), the expression of HMGB-1 by Western blot, and serum levels of HMGB-1, 
      liver function and hepatic pathology were observed after artificial liver support 
      system treatment. The levels of TNF-alpha and IL-1 beta were increased and 
      reached the peak at 24th h in the acute hepatic failure group, then quickly 
      decreased. The serum level of HMGB-1 was increased at 24th h in the acute hepatic 
      failure group and reached the peak at 48th h, then kept a stable high level. 
      Significant liver injury appeared at 24th h and was continuously getting worse in 
      the pig models of acute hepatic failure. In contrast, the liver injury was 
      significantly alleviated and serum level of HMGB-1 was significantly decreased in 
      the group treated with artificial liver support system (P<0.05). It was suggested 
      that HMGB-1 may participate in the inflammatory response and liver injury in the 
      late stage of the acute liver failure. Artificial liver support system treatment 
      can reduce serum HMGB-1 level and relieve liver pathological damage.
FAU - Zhang, Fan
AU  - Zhang F
AD  - Department of Infectious Disease, Union Hospital, Tongji Medical Colleage, 
      Huazhong University of Science and Technology, Wuhan 430022, China. 
      zf77361@yahoo.com.cn
FAU - He, Yongwen
AU  - He Y
FAU - Duan, Zhongping
AU  - Duan Z
LA  - eng
PT  - Journal Article
PL  - China
TA  - J Huazhong Univ Sci Technolog Med Sci
JT  - Journal of Huazhong University of Science and Technology. Medical sciences = Hua 
      zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. 
      Yixue Yingdewen ban
JID - 101169627
RN  - 0 (HMGB1 Protein)
RN  - 0 (Interleukin-1beta)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Animals
MH  - Cholestasis
MH  - Disease Models, Animal
MH  - *Gene Expression Regulation
MH  - HMGB1 Protein/blood/metabolism/*physiology
MH  - Interleukin-1beta/blood
MH  - Liver/*metabolism
MH  - Liver Failure/*blood/*metabolism
MH  - Liver, Artificial
MH  - Necrosis
MH  - Swine
MH  - Time Factors
MH  - Tumor Necrosis Factor-alpha/blood
EDAT- 2008/02/19 09:00
MHDA- 2008/11/18 09:00
CRDT- 2008/02/19 09:00
PHST- 2007/08/30 00:00 [received]
PHST- 2008/02/19 09:00 [pubmed]
PHST- 2008/11/18 09:00 [medline]
PHST- 2008/02/19 09:00 [entrez]
AID - 10.1007/s11596-008-0113-x [doi]
PST - ppublish
SO  - J Huazhong Univ Sci Technolog Med Sci. 2008 Feb;28(1):52-5. doi: 
      10.1007/s11596-008-0113-x.