PMID- 18279072
OWN - NLM
STAT- MEDLINE
DCOM- 20080605
LR  - 20111117
IS  - 0022-1899 (Print)
IS  - 0022-1899 (Linking)
VI  - 197
IP  - 6
DP  - 2008 Mar 15
TI  - A nonprogressive clinical course in HIV-infected individuals expressing human 
      leukocyte antigen B57/5801 is associated with preserved CD8+ T lymphocyte 
      responsiveness to the HW9 epitope in Nef.
PG  - 871-9
LID - 10.1086/528695 [doi]
AB  - The human leukocyte antigen (HLA) B57 allele and the closely related HLA-B5801 
      allele are overrepresented among human immunodeficiency virus type 1 
      (HIV-1)-infected individuals with a long-term nonprogressive clinical course of 
      disease (known as "long-term nonprogressors" [LTNPs]). These alleles are, 
      however, also present among individuals with normal disease progression (known as 
      "progressors"). In a comparison of HLA-B57/5801-expressing progressors and LTNPs, 
      we observed a similar prevalence of escape mutations in 4 Nef epitopes and a 
      similar reactivity of CD8+ T cells against 3 of 4 of these epitopes and their 
      autologous escape variants. However, LTNPs tended to have frequent and preserved 
      CD8+ T cell interferon-gamma responses against the wild-type HW9 Nef epitope, 
      whereas progressors did not maintain a specific CD8+ T cell response. This 
      finding is in line with the findings of a more exhausted phenotype of CD8+ T 
      cells in progressors, as is demonstrated by their enhanced level of expression of 
      inhibitory receptor "programmed death 1" (PD-1). The results of the present study 
      suggest that preservation of HW9-specific T cell responses is associated with a 
      more benign clinical course of infection.
FAU - Navis, Marjon
AU  - Navis M
AD  - Sanquin Research, Landsteiner Laboratory, and Center for Infectious Diseases and 
      Immunity Amsterdam at the Academic Medical Center, Amsterdam, The Netherlands.
FAU - Schellens, Ingrid M M
AU  - Schellens IM
FAU - van Swieten, Peter
AU  - van Swieten P
FAU - Borghans, Jose A M
AU  - Borghans JA
FAU - Miedema, Frank
AU  - Miedema F
FAU - Kootstra, Neeltje A
AU  - Kootstra NA
FAU - van Baarle, Debbie
AU  - van Baarle D
FAU - Schuitemaker, Hanneke
AU  - Schuitemaker H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
RN  - 0 (Antigens, CD)
RN  - 0 (Apoptosis Regulatory Proteins)
RN  - 0 (Epitopes, T-Lymphocyte)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-B57 antigen)
RN  - 0 (PDCD1 protein, human)
RN  - 0 (Programmed Cell Death 1 Receptor)
RN  - 0 (nef Gene Products, Human Immunodeficiency Virus)
RN  - 0 (nef protein, Human immunodeficiency virus 1)
SB  - IM
MH  - Antigens, CD/biosynthesis/immunology
MH  - Apoptosis Regulatory Proteins/biosynthesis/immunology
MH  - CD4 Lymphocyte Count
MH  - Cohort Studies
MH  - Epitopes, T-Lymphocyte/genetics/*immunology
MH  - HIV Infections/genetics/*immunology/virology
MH  - HIV Long-Term Survivors
MH  - HIV-1/*immunology
MH  - HLA-B Antigens/*biosynthesis/genetics/immunology
MH  - Humans
MH  - Programmed Cell Death 1 Receptor
MH  - T-Lymphocytes, Cytotoxic/*immunology
MH  - nef Gene Products, Human Immunodeficiency Virus/genetics/*immunology
EDAT- 2008/02/19 09:00
MHDA- 2008/06/06 09:00
CRDT- 2008/02/19 09:00
PHST- 2008/02/19 09:00 [pubmed]
PHST- 2008/06/06 09:00 [medline]
PHST- 2008/02/19 09:00 [entrez]
AID - 10.1086/528695 [doi]
PST - ppublish
SO  - J Infect Dis. 2008 Mar 15;197(6):871-9. doi: 10.1086/528695.