PMID- 18279205
OWN - NLM
STAT- MEDLINE
DCOM- 20080611
LR  - 20160511
IS  - 1328-8067 (Print)
IS  - 1328-8067 (Linking)
VI  - 50
IP  - 1
DP  - 2008 Feb
TI  - Asthma, lung function and sensitization in school children with a history of 
      bronchiolitis.
PG  - 51-6
LID - 10.1111/j.1442-200X.2007.02509.x [doi]
AB  - BACKGROUND: The purpose of the present retrospective study was to investigate the 
      association of school-age asthma with acute-bronchiolitis and examine the 
      influence of potential risk factors. METHODS: One hundred and eighty-nine 
      children aged 7.5 +/- 2.2 years consecutively hospitalized for respiratory 
      syncytial virus (RSV)-positive acute bronchiolitis during infancy were evaluated 
      by clinical examination and measurement of peak expiratory flow (PEFR), 
      spirometry, IgE and skin-prick testing. Their pulmonary function was compared 
      with that of 60 non-asthmatic matched controls. RESULTS: Of the entire cohort 
      57.1% were diagnosed as asthmatic. PEFR, the 1-second forced expiratory volume 
      and forced expiratory flow of 50% vital capacity of children with a history of 
      acute bronchiolitis were statistically significantly lower than in the control 
      group (all P < 0.001). All the aforementioned measurements of children 
      with/without asthma were also significantly lower than controls, while values of 
      asthmatics were significantly lower than those of non-asthmatics. The incidence 
      of asthma in childhood was independently associated with breast-feeding <3 months 
      (adjusted odds ratio [aOR], 8.4; 95% confidence interval [CI]: 3.1-22.4), at 
      least one positive skin prick test (aOR, 7.1; 95%CI: 2.8-18.1), male gender (aOR, 
      5.0; 95%CI: 2.2-11.5), evidence of moisture in the home environment (aOR, 2.9; 
      95%CI: 1.3-6.3) and presence of more than one house-resident smoking indoors 
      (aOR, 4.9; 95%CI: 1.8-9.2). CONCLUSION: Children with a history of 
      RSV-bronchiolitis during infancy have an increased risk for developing asthma in 
      childhood, which was independently associated with male gender, breast-feeding <3 
      months, living in a home environment with moisture damage and/or tobacco smoke by 
      two or more residents and sensitization to at least one aeroallergen. Children 
      with a history of RSV bronchiolitis in infancy had lower spirometry in comparison 
      to matched control group. The difference was more marked for asthmatic ones but 
      remained significant even for non-asthmatic children.
FAU - Cassimos, Dimitrios C
AU  - Cassimos DC
AD  - Department of Paediatrics, Univesity General Hospital of Alexandroupolis, 
      Democritus University of Thrace, Alexandroupolis, Greece. kassimos@pathfinder.gr
FAU - Tsalkidis, Aggelos
AU  - Tsalkidis A
FAU - Tripsianis, Gregorios A
AU  - Tripsianis GA
FAU - Stogiannidou, Anastasia
AU  - Stogiannidou A
FAU - Anthracopoulos, Michael
AU  - Anthracopoulos M
FAU - Ktenidou-Kartali, Sofia
AU  - Ktenidou-Kartali S
FAU - Aivazis, Victor
AU  - Aivazis V
FAU - Gardikis, Stefanos
AU  - Gardikis S
FAU - Chatzimichael, Athanasios
AU  - Chatzimichael A
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - Pediatr Int
JT  - Pediatrics international : official journal of the Japan Pediatric Society
JID - 100886002
SB  - IM
CIN - Pediatr Int. 2009 Apr;51(2):313. PMID: 19379269
MH  - Adolescent
MH  - Asthma/*etiology/*physiopathology
MH  - Bronchitis/*complications
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Humans
MH  - Lung/*physiopathology
MH  - Male
MH  - Respiratory Function Tests
MH  - Respiratory Hypersensitivity/*complications
MH  - Respiratory Syncytial Virus Infections/*complications
MH  - Retrospective Studies
EDAT- 2008/02/19 09:00
MHDA- 2008/06/12 09:00
CRDT- 2008/02/19 09:00
PHST- 2008/02/19 09:00 [pubmed]
PHST- 2008/06/12 09:00 [medline]
PHST- 2008/02/19 09:00 [entrez]
AID - PED2509 [pii]
AID - 10.1111/j.1442-200X.2007.02509.x [doi]
PST - ppublish
SO  - Pediatr Int. 2008 Feb;50(1):51-6. doi: 10.1111/j.1442-200X.2007.02509.x.