PMID- 18279555
OWN - NLM
STAT- MEDLINE
DCOM- 20081027
LR  - 20090520
IS  - 1475-2662 (Electronic)
IS  - 0007-1145 (Linking)
VI  - 100
IP  - 2
DP  - 2008 Aug
TI  - Effects of dietary cholesterol and fat on serum non-cholesterol sterols according 
      to different apolipoprotein E subgroups among healthy men.
PG  - 373-9
LID - 10.1017/S0007114508894330 [doi]
AB  - The impact of apo E phenotypes on applicability of relative cholesterol synthesis 
      (lathosterol:cholesterol) and absorption (ratios of cholestanol, campesterol and 
      sitosterol to cholesterol) during diets of various cholesterol and fat content is 
      unclear. We examined and compared with each other both relative and absolute 
      synthesis and absorption among twenty-nine men, of whom eight, nine and twelve 
      had apo E phenotypes 2 (2/2, 2/3, 2/4), 3 (3/3) and 4 (3/4, 4/4), respectively. 
      Serum lipids, lipoproteins, sterols and cholesterol metabolism were examined on 
      four subsequent diets: high-cholesterol high-fat (home diet; HD), low-cholesterol 
      low-fat (LCLF), high-cholesterol low-fat (HCLF) and low-cholesterol high-fat 
      (LCHF). LDL-cholesterol (LDL-C) level was about 40 % lower (P < 0.05) in apo E2 
      than apo E3 and E4 groups irrespective of dietary fat and cholesterol. Serum 
      proportions of phytosterols were determined apo E-dependently on LCLF and HCLF, 
      and those of lathosterol, cholestanol and campesterol were increased in apo E2 
      and E3 groups (P < 0.05 for each v. HD). Serum proportion of sitosterol reflected 
      almost consistently apo E phenotype (r range+0.308 to+0.383; P range 
      0.214-0.011). Relative cholesterol synthesis and absorption reflected respective 
      absolute values during each diet in the apo E4 group (r range+0.713 to+0.893; P < 
      0.05 for each), but only during HD (r+0.594; P = 0.015) in the apo E2+E3 group. 
      The consumption of a high amount of fat did not interfere with cholesterol 
      metabolism or serum levels of LDL-C differently in apo E phenotypes. Surrogate 
      sterol markers of cholesterol metabolism reflected absolute ones (especially in 
      the apo E4 group) and apo E phenotypes despite variable amounts of dietary 
      cholesterol and fat.
FAU - Nissinen, Markku J
AU  - Nissinen MJ
AD  - Division of Gastroenterology, Department of Medicine, University of Helsinki, 
      C422, POB 700, Helsinki FI-00029, Finland. markku.nissinen@dlc.fi
FAU - Gylling, Helena
AU  - Gylling H
FAU - Miettinen, Tatu A
AU  - Miettinen TA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080218
PL  - England
TA  - Br J Nutr
JT  - The British journal of nutrition
JID - 0372547
RN  - 0 (Apolipoproteins E)
RN  - 0 (Cholesterol, Dietary)
RN  - 0 (Cholesterol, LDL)
RN  - 0 (Dietary Fats)
RN  - 0 (Lipids)
RN  - 0 (Lipoproteins)
RN  - 0 (Sterols)
SB  - IM
MH  - Apolipoproteins E/*blood
MH  - Cholesterol, Dietary/pharmacokinetics/*pharmacology
MH  - Cholesterol, LDL/blood
MH  - Diet
MH  - Dietary Fats/*pharmacology
MH  - Humans
MH  - Intestinal Absorption
MH  - Lipids/blood
MH  - Lipoproteins/blood
MH  - Male
MH  - Middle Aged
MH  - Phenotype
MH  - Sterols/*blood
EDAT- 2008/02/19 09:00
MHDA- 2008/10/28 09:00
CRDT- 2008/02/19 09:00
PHST- 2008/02/19 09:00 [pubmed]
PHST- 2008/10/28 09:00 [medline]
PHST- 2008/02/19 09:00 [entrez]
AID - S0007114508894330 [pii]
AID - 10.1017/S0007114508894330 [doi]
PST - ppublish
SO  - Br J Nutr. 2008 Aug;100(2):373-9. doi: 10.1017/S0007114508894330. Epub 2008 Feb 
      18.