PMID- 18279773
OWN - NLM
STAT- MEDLINE
DCOM- 20080528
LR  - 20220408
IS  - 1388-9842 (Print)
IS  - 1388-9842 (Linking)
VI  - 10
IP  - 2
DP  - 2008 Feb
TI  - Worsening renal function in patients hospitalised for acute heart failure: 
      clinical implications and prognostic significance.
PG  - 188-95
LID - 10.1016/j.ejheart.2008.01.011 [doi]
AB  - BACKGROUND: Renal function is a powerful prognostic variable in patients with 
      heart failure (HF). Hospitalisations for acute HF (AHF) may be associated with 
      further worsening of renal function (WRF). METHODS AND RESULTS: We analysed the 
      clinical significance of WRF in 318 consecutive patients admitted at our 
      institute for AHF. WRF was defined as the occurrence, at any time during the 
      hospitalisation, of both a > or =25% and a > or =0.3 mg/dL increase in serum 
      creatinine (s-Cr) from admission (WRF-Abs-%). RESULTS: Patients were followed for 
      480+/-363 days. Fifty-three patients (17%) died and 132 (41%) were rehospitalised 
      for HF. WRF-Abs-% occurred in 107 (34%) patients. At multivariable survival 
      analysis, WRF-Abs-% was an independent predictor of death or HF rehospitalisation 
      (adjusted HR, 1.47; 95%CI, 1.13-1.81; p=0.024). The independent predictors of 
      WRF-Abs-%, evaluated using multivariable logistic regression, were history of 
      chronic kidney disease (p=0.002), LV ejection fraction (p=0.012), furosemide 
      daily dose (p=0.03) and NYHA class (p=0.05) on admission. CONCLUSION: WRF is a 
      frequent finding in patients hospitalised for AHF and is associated with a poor 
      prognosis. Severity of HF and daily furosemide dose are the most important 
      predictors of the occurrence of WRF.
FAU - Metra, Marco
AU  - Metra M
AD  - Section on Cardiovascular Diseases, Department of Experimental and Applied 
      Medicine, University of Brescia, Italy. metramarco@libero.it
FAU - Nodari, Savina
AU  - Nodari S
FAU - Parrinello, Giovanni
AU  - Parrinello G
FAU - Bordonali, Tania
AU  - Bordonali T
FAU - Bugatti, Silvia
AU  - Bugatti S
FAU - Danesi, Rossella
AU  - Danesi R
FAU - Fontanella, Benedetta
AU  - Fontanella B
FAU - Lombardi, Carlo
AU  - Lombardi C
FAU - Milani, Patrizia
AU  - Milani P
FAU - Verzura, Giulia
AU  - Verzura G
FAU - Cotter, Gadi
AU  - Cotter G
FAU - Dittrich, Howard
AU  - Dittrich H
FAU - Massie, Barry M
AU  - Massie BM
FAU - Dei Cas, Livio
AU  - Dei Cas L
LA  - eng
PT  - Journal Article
PL  - England
TA  - Eur J Heart Fail
JT  - European journal of heart failure
JID - 100887595
RN  - 0 (Diuretics)
RN  - 7LXU5N7ZO5 (Furosemide)
RN  - AYI8EX34EU (Creatinine)
SB  - IM
MH  - Aged
MH  - Creatinine/blood
MH  - Diuretics/administration & dosage
MH  - Female
MH  - Furosemide/administration & dosage
MH  - Heart Failure/mortality/*physiopathology
MH  - Hospitalization
MH  - Humans
MH  - Kidney/*physiopathology
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Prospective Studies
MH  - Survival Analysis
EDAT- 2008/02/19 09:00
MHDA- 2008/05/29 09:00
CRDT- 2008/02/19 09:00
PHST- 2007/09/29 00:00 [received]
PHST- 2008/01/12 00:00 [revised]
PHST- 2008/01/21 00:00 [accepted]
PHST- 2008/02/19 09:00 [pubmed]
PHST- 2008/05/29 09:00 [medline]
PHST- 2008/02/19 09:00 [entrez]
AID - S1388-9842(08)00013-5 [pii]
AID - 10.1016/j.ejheart.2008.01.011 [doi]
PST - ppublish
SO  - Eur J Heart Fail. 2008 Feb;10(2):188-95. doi: 10.1016/j.ejheart.2008.01.011.