PMID- 18280018
OWN - NLM
STAT- MEDLINE
DCOM- 20081117
LR  - 20161124
IS  - 1873-6424 (Electronic)
IS  - 0269-7491 (Linking)
VI  - 156
IP  - 1
DP  - 2008 Nov
TI  - Coupled mother-child model for bioaccumulation of POPs in nursing infants.
PG  - 90-8
LID - 10.1016/j.envpol.2007.12.036 [doi]
AB  - Bioaccumulation of persistent organic pollutants (POPs) leads to high levels in 
      human milk and high doses of POPs for nursing infants. This is currently not 
      considered in chemical risk assessment. A coupled model for bioaccumulation of 
      organic chemicals in breast-feeding mother and nursing infant was developed and 
      tested for a series of organic compounds. The bioaccumulation factors (BAFs) in 
      mother, breast milk and child were predicted to vary with logK(OW) and, for 
      volatile compounds, with K(AW) and concentration in air. The concentrations of 
      POPs in the infant body increase the first half year to about factor 3 above 
      mother and decline thereafter to lower levels. The predicted results are close to 
      empirical data and to an empirical regression. The new mother-child model is 
      compact due to its easy structure and the analytical matrix solution. It could be 
      added to existing exposure and risk assessment systems, such as EUSES.
FAU - Trapp, Stefan
AU  - Trapp S
AD  - Technical University of Denmark, Department of Environmental Engineering, 
      Bygningstorvet 115, DK-2800 Kongens Lyngby, Denmark. stt@env.dtu.dk
FAU - Bomholtz, Li Ma
AU  - Bomholtz LM
FAU - Legind, Charlotte N
AU  - Legind CN
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080214
PL  - England
TA  - Environ Pollut
JT  - Environmental pollution (Barking, Essex : 1987)
JID - 8804476
RN  - 0 (Environmental Pollutants)
RN  - 0 (Organic Chemicals)
RN  - 0 (Polychlorinated Dibenzodioxins)
SB  - IM
MH  - Adipose Tissue/metabolism
MH  - *Breast Feeding
MH  - Environmental Pollutants/*pharmacokinetics
MH  - Food Contamination
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Inhalation Exposure
MH  - Lactation/physiology
MH  - Milk, Human/*chemistry
MH  - *Models, Biological
MH  - Organic Chemicals/*pharmacokinetics
MH  - Polychlorinated Dibenzodioxins/pharmacokinetics
EDAT- 2008/02/19 09:00
MHDA- 2008/11/18 09:00
CRDT- 2008/02/19 09:00
PHST- 2007/07/10 00:00 [received]
PHST- 2007/12/05 00:00 [revised]
PHST- 2007/12/22 00:00 [accepted]
PHST- 2008/02/19 09:00 [pubmed]
PHST- 2008/11/18 09:00 [medline]
PHST- 2008/02/19 09:00 [entrez]
AID - S0269-7491(08)00006-7 [pii]
AID - 10.1016/j.envpol.2007.12.036 [doi]
PST - ppublish
SO  - Environ Pollut. 2008 Nov;156(1):90-8. doi: 10.1016/j.envpol.2007.12.036. Epub 
      2008 Feb 14.