PMID- 18280799 OWN - NLM STAT- MEDLINE DCOM- 20080624 LR - 20081022 IS - 1569-9048 (Print) IS - 1569-9048 (Linking) VI - 161 IP - 1 DP - 2008 Mar 20 TI - Immunohistochemical characterization of the rat carotid body. PG - 95-9 LID - 10.1016/j.resp.2007.12.008 [doi] AB - We studied the histochemical phenotype of carotid body (CB) cells in the adult rat. In addition to tyrosine hydroxylase (TH), type I cells expressed numerous growth factors such as glial cell line-derived neurotrophic factor (GDNF), basic fibroblast growth factor (bFGF), brain-derived neurotrophic factor (BDNF), ciliary neurotrophic factor (CNTF), insulin-like growth factor-I (IGF-I), epidermal growth factor (EGF) and transforming growth factor-alpha (TGF-alpha), as well as the receptors p75, Ret, epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor-alpha (PDGFR-alpha). Type II cells expressed the glial fibrillary acid protein (GFAP), vimentin, the trophic factor bFGF and receptors p75, EGFR and PDGFR-alpha. Both types I and II cells exhibited a positive immunoreaction to markers of neural progenitor cells such as the polysialylated form of the neural cell adhesion molecule (PSA-NCAM) and nestin, respectively, suggesting that CB contain some immature cells even at the adult stage. The possibility that these cells can be expanded and differentiated into mature neurons should be explored. FAU - Izal-Azcarate, Amaya AU - Izal-Azcarate A AD - Department of Neuroscience, Centre for Applied Medical Research-University of Navarra, Avda. Pio XII 55, 31008 Pamplona, Navarra, Spain. FAU - Belzunegui, Silvia AU - Belzunegui S FAU - San Sebastian, Waldy AU - San Sebastian W FAU - Garrido-Gil, Pablo AU - Garrido-Gil P FAU - Vazquez-Claverie, Marianne AU - Vazquez-Claverie M FAU - Lopez, Berta AU - Lopez B FAU - Marcilla, Irene AU - Marcilla I FAU - Luquin, M A Rosario AU - Luquin MA LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20080108 PL - Netherlands TA - Respir Physiol Neurobiol JT - Respiratory physiology & neurobiology JID - 101140022 RN - 0 (Intercellular Signaling Peptides and Proteins) SB - IM MH - Animals MH - Carotid Body/*cytology/*metabolism MH - Immunohistochemistry MH - Intercellular Signaling Peptides and Proteins/biosynthesis MH - Male MH - Rats MH - Rats, Wistar MH - Stem Cells/cytology EDAT- 2008/02/19 09:00 MHDA- 2008/06/25 09:00 CRDT- 2008/02/19 09:00 PHST- 2007/11/28 00:00 [received] PHST- 2007/12/18 00:00 [revised] PHST- 2007/12/21 00:00 [accepted] PHST- 2008/02/19 09:00 [pubmed] PHST- 2008/06/25 09:00 [medline] PHST- 2008/02/19 09:00 [entrez] AID - S1569-9048(07)00344-8 [pii] AID - 10.1016/j.resp.2007.12.008 [doi] PST - ppublish SO - Respir Physiol Neurobiol. 2008 Mar 20;161(1):95-9. doi: 10.1016/j.resp.2007.12.008. Epub 2008 Jan 8.