PMID- 18281111
OWN - NLM
STAT- MEDLINE
DCOM- 20080721
LR  - 20080318
IS  - 0167-0115 (Print)
IS  - 0167-0115 (Linking)
VI  - 147
IP  - 1-3
DP  - 2008 Apr 10
TI  - Differential inhibition of galanin- and ghrelin-induced food intake by i.c.v. 
      GLP-1(7-36)-amide.
PG  - 29-32
LID - 10.1016/j.regpep.2007.12.004 [doi]
AB  - Feeding regulation involves both anorectic and orexigenic neuropeptides mainly 
      located in the hypothalamus. To gain further insight into the interaction between 
      these two groups of regulators inhibition of feeding induced by glucagon-like 
      peptide-1 (GLP-1) was examined during stimulation of food intake by equimolar 
      doses of ghrelin and galanin. The experiments were carried out in freely feeding 
      rats. Intracerebroventricular (i.c.v.) injections were accomplished through 
      stereotaxically implanted cannulae aimed at the lateral cerebral ventricle. Food 
      intake of standard rat chow pellets was subsequently recorded for 2 h. Ghrelin 
      and galanin stimulated food intake significantly with no difference between these 
      two peptides. During ghrelin stimulation GLP-1 inhibited feeding in doses between 
      0.015 and 1.5 nmol. During galanin stimulation of food intake a ten fold higher 
      dose (0.15 nmol) was required to inhibit food intake. In conclusion equimolar 
      doses of i.c.v. ghrelin and galanin are similarly effective stimuli of food 
      intake when given alone. However in combination with an anorectic neuropeptide 
      such as GLP-1 they have substantially different potencies of feeding stimulation. 
      Such interaction could also be of interest for therapeutic strategies involving 
      both regulating groups of neuropeptides.
FAU - Schusdziarra, Volker
AU  - Schusdziarra V
AD  - Else-Kroner-Fresenius Center of Nutritional Medicine, Technical University of 
      Munich, Germany. volker.schusdziarra@lrz.tum.de
FAU - Zimmermann, Jens-Peter
AU  - Zimmermann JP
FAU - Erdmann, Johannes
AU  - Erdmann J
FAU - Bader, Ulrich
AU  - Bader U
FAU - Schick, Rafael R
AU  - Schick RR
LA  - eng
PT  - Journal Article
DEP - 20071228
PL  - Netherlands
TA  - Regul Pept
JT  - Regulatory peptides
JID - 8100479
RN  - 0 (Ghrelin)
RN  - 0 (Peptide Fragments)
RN  - 119637-73-9 (glucagon-like peptide 1 (7-36)amide)
RN  - 88813-36-9 (Galanin)
RN  - 89750-14-1 (Glucagon-Like Peptide 1)
SB  - IM
MH  - Animals
MH  - Eating/*drug effects
MH  - Galanin/administration & dosage/*antagonists & inhibitors
MH  - Ghrelin/administration & dosage/*antagonists & inhibitors
MH  - Glucagon-Like Peptide 1/administration & dosage/*pharmacology
MH  - Injections, Intraventricular
MH  - Male
MH  - Peptide Fragments/administration & dosage/*pharmacology
MH  - Rats
MH  - Rats, Wistar
EDAT- 2008/02/19 09:00
MHDA- 2008/07/22 09:00
CRDT- 2008/02/19 09:00
PHST- 2007/08/27 00:00 [received]
PHST- 2007/11/19 00:00 [revised]
PHST- 2007/12/20 00:00 [accepted]
PHST- 2008/02/19 09:00 [pubmed]
PHST- 2008/07/22 09:00 [medline]
PHST- 2008/02/19 09:00 [entrez]
AID - S0167-0115(07)00259-5 [pii]
AID - 10.1016/j.regpep.2007.12.004 [doi]
PST - ppublish
SO  - Regul Pept. 2008 Apr 10;147(1-3):29-32. doi: 10.1016/j.regpep.2007.12.004. Epub 
      2007 Dec 28.