PMID- 18281137
OWN - NLM
STAT- MEDLINE
DCOM- 20080702
LR  - 20131121
IS  - 0278-5846 (Print)
IS  - 0278-5846 (Linking)
VI  - 32
IP  - 3
DP  - 2008 Apr 1
TI  - Association of missense variants of the PRKC, apoptosis, WT1, regulator (PAWR) 
      gene with schizophrenia.
PG  - 870-5
LID - 10.1016/j.pnpbp.2008.01.003 [doi]
AB  - Abnormal dopamine signal transduction is implicated in the pathophysiology of 
      schizophrenia. A recent study showed that prostate apoptosis response 4 protein 
      (Par-4) interacts with dopamine D2 receptor and plays an important role in 
      dopamine signaling. Par-4 knockout mice showed depression-like behavior, 
      suggesting that Par-4 gene may be associated with mental disorders in human. The 
      study was aimed to determine whether the PRKC, apoptosis, WT1, regulator gene 
      (PAWR) that encodes the human homolog of Par-4 protein is a susceptibility gene 
      for schizophrenia. We systematically screened for mutations at the 5' 
      untranslated region (5'UTR) and all the exonic regions of the PAWR gene in a 
      sample of Han Chinese schizophrenic patients from Taiwan. We identified two 
      missense single nucleotide polymorphisms (SNPs) that are in strong linkage in our 
      sample (D'=0.98), i.e. P78R at exon 2 and I199M at exon 3, respectively. SNP- and 
      haplotype-based analysis showed that these two variants are associated with 
      schizophrenia; there is an overrepresentation of RR homozygotes of P78R (OR=2.00, 
      95% CI=1.05-3.83) and MM homozygotes of I199M (OR=1.81, 95% CI=0.95-3.54) in 
      schizophrenic patients as compared to control subjects. When subjects were 
      divided by gender, the association is specifically with female patients (OR=2.94 
      for RR and OR=2.7 for MM), but not with male patients. Our results indicate that 
      the PAWR gene is associated with schizophrenia in our population, and this study 
      provides genetic evidence to support the dopamine hypothesis of schizophrenia.
FAU - Wang, Ling-Hsuan
AU  - Wang LH
AD  - Institute of Human Genetics, Tzu-Chi University, Hualien 970, Taiwan.
FAU - Chen, Jen-Yeu
AU  - Chen JY
FAU - Liou, Ying-Jay
AU  - Liou YJ
FAU - Wang, Ying-Chieh
AU  - Wang YC
FAU - Lai, I-Ching
AU  - Lai IC
FAU - Liao, Ding-Lieh
AU  - Liao DL
FAU - Chen, Chia-Hsiang
AU  - Chen CH
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080111
PL  - England
TA  - Prog Neuropsychopharmacol Biol Psychiatry
JT  - Progress in neuro-psychopharmacology & biological psychiatry
JID - 8211617
RN  - 0 (5' Untranslated Regions)
RN  - 0 (Apoptosis Regulatory Proteins)
RN  - 0 (prostate apoptosis response-4 protein)
RN  - 04Y7590D77 (Isoleucine)
RN  - 94ZLA3W45F (Arginine)
RN  - 9DLQ4CIU6V (Proline)
RN  - AE28F7PNPL (Methionine)
SB  - IM
MH  - 5' Untranslated Regions/metabolism
MH  - Adult
MH  - Apoptosis Regulatory Proteins/*genetics
MH  - Arginine/genetics
MH  - DNA Mutational Analysis
MH  - Female
MH  - *Genetic Predisposition to Disease
MH  - Humans
MH  - Isoleucine/genetics
MH  - Male
MH  - Methionine/genetics
MH  - Middle Aged
MH  - Mutation, Missense/*genetics
MH  - Polymorphism, Genetic
MH  - Proline/genetics
MH  - Schizophrenia/*genetics
MH  - Sex Factors
MH  - Taiwan
EDAT- 2008/02/19 09:00
MHDA- 2008/07/03 09:00
CRDT- 2008/02/19 09:00
PHST- 2007/11/21 00:00 [received]
PHST- 2007/12/24 00:00 [revised]
PHST- 2008/01/03 00:00 [accepted]
PHST- 2008/02/19 09:00 [pubmed]
PHST- 2008/07/03 09:00 [medline]
PHST- 2008/02/19 09:00 [entrez]
AID - S0278-5846(08)00009-2 [pii]
AID - 10.1016/j.pnpbp.2008.01.003 [doi]
PST - ppublish
SO  - Prog Neuropsychopharmacol Biol Psychiatry. 2008 Apr 1;32(3):870-5. doi: 
      10.1016/j.pnpbp.2008.01.003. Epub 2008 Jan 11.