PMID- 18282273
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20220330
IS  - 1476-9255 (Electronic)
IS  - 1476-9255 (Linking)
VI  - 5
DP  - 2008 Feb 18
TI  - Does CD4+CD25+foxp3+ cell (Treg) and IL-10 profile determine susceptibility to 
      immune reconstitution inflammatory syndrome (IRIS) in HIV disease?
PG  - 2
LID - 10.1186/1476-9255-5-2 [doi]
AB  - HIV-specific T-lymphocyte responses that underlie IRIS are incomplete and largely 
      remain hypothetical. Of the several mechanisms presented by the host to control 
      host immunological damage, Treg cells are believed to play a critical role. Using 
      the available experimental evidence, it is proposed that enormous synthesis of 
      conventional FoxP3- Th cells (responsive) often renders subjects inherently 
      vulnerable to IRIS, whereas that of natural FoxP3+ Treg cell synthesis 
      predominate among subjects that may not progress to IRIS. We also propose that 
      IRIS non-developers generate precursor T-cells with a high avidity to generate 
      CD4+CD25+FoxP3+ Tregs whereas IRIS developers generate T-cells of intermediate 
      avidity yielding Th0 cells and effector T-cells to mediate the generation of 
      proinflammatory cytokines in response to cell-signaling factors (IL-2, IL-6 
      etc.). Researchers have shown that IL-10 Tregs (along with TGF-beta, a known 
      anti-inflammatory cytokine) limit immune responses against microbial antigens in 
      addition to effectively controlling HIV replication, the prime objective of 
      HAART. Although certain technical limitations are described herein, we advocate 
      measures to test the role of Tregs in IRIS.
FAU - Shankar, Esaki Muthu
AU  - Shankar EM
AD  - YRG Centre for AIDS Research and Education, VHS Hospital Campus, Rajiv Gandhi 
      Salai-Information Technology Corridor, Taramani, Chennai 600 113, India. 
      kumarasamy@yrgcare.org.
FAU - Vignesh, Ramachandran
AU  - Vignesh R
FAU - Velu, Vijayakumar
AU  - Velu V
FAU - Murugavel, Kailapuri G
AU  - Murugavel KG
FAU - Sekar, Ramalingam
AU  - Sekar R
FAU - Balakrishnan, Pachamuthu
AU  - Balakrishnan P
FAU - Lloyd, Charmaine Ac
AU  - Lloyd CA
FAU - Saravanan, Shanmugam
AU  - Saravanan S
FAU - Solomon, Suniti
AU  - Solomon S
FAU - Kumarasamy, Nagalingeswaran
AU  - Kumarasamy N
LA  - eng
PT  - Journal Article
DEP - 20080218
PL  - England
TA  - J Inflamm (Lond)
JT  - Journal of inflammation (London, England)
JID - 101232234
PMC - PMC2265708
EDAT- 2008/02/20 09:00
MHDA- 2008/02/20 09:01
PMCR- 2008/02/18
CRDT- 2008/02/20 09:00
PHST- 2007/11/26 00:00 [received]
PHST- 2008/02/18 00:00 [accepted]
PHST- 2008/02/20 09:00 [pubmed]
PHST- 2008/02/20 09:01 [medline]
PHST- 2008/02/20 09:00 [entrez]
PHST- 2008/02/18 00:00 [pmc-release]
AID - 1476-9255-5-2 [pii]
AID - 10.1186/1476-9255-5-2 [doi]
PST - epublish
SO  - J Inflamm (Lond). 2008 Feb 18;5:2. doi: 10.1186/1476-9255-5-2.