PMID- 18282492
OWN - NLM
STAT- MEDLINE
DCOM- 20080401
LR  - 20220317
IS  - 0002-9394 (Print)
IS  - 0002-9394 (Linking)
VI  - 145
IP  - 3
DP  - 2008 Mar
TI  - Human leukocyte antigen-B27-associated uveitis: long-term follow-up and gender 
      differences.
PG  - 472-9
LID - 10.1016/j.ajo.2007.11.009 [doi]
AB  - PURPOSE: To evaluate clinical features and gender differences in human leukocyte 
      antigen (HLA)-B27-associated acute anterior uveitis (AAU) in long-term follow-up. 
      DESIGN: Retrospective cohort study. METHODS: The clinical records of 177 
      HLA-B27-positive patients (96 males [54%] and 81 females [46%]) who sought 
      treatment for acute anterior uveitis (AAU) at the University Medical Center 
      Utrecht between January 1995 and December 2005 were evaluated. All patients had a 
      minimum follow-up of at least one year. The clinical data were analyzed at 
      standardized intervals (one, five, and 10 years after the onset of uveitis). 
      RESULTS: Average age at onset of AAU was 36 years, with no differences between 
      males and females. HLA-B27-associated systemic disease developed earlier in males 
      than in females (31 vs 37 years; P=.021). Consequently, at onset of AAU, 
      HLA-B27-associated systemic disease were more frequent in males than in females 
      (25/75 [33%] males vs nine/54 [17%] females; P=.030); however over time, males 
      and females were at equal risk of developing a HLA-B27-associated systemic 
      disease. Bilateral uveitis developed more frequently in females (6/45 [13%] of 
      males vs 11/35, [31%] of females; P=.05). In none of the patients did bilateral 
      visual acuity of less than 0.5 develop after the follow-up of 10 years. 
      CONCLUSIONS: The long-term visual prognosis of HLA-B27-associated AAU was 
      favorable, despite the frequent attacks of severe AAU. At the onset of AAU, the 
      prevalence of HLA-B27-associated systemic disease was more frequent in males, but 
      after the onset of uveitis, the risk of developing a HLA-B27-associated systemic 
      disease is similar for both males and females.
FAU - Braakenburg, Arthur M D
AU  - Braakenburg AM
AD  - FC Donders Institute of Ophthalmology, University Medical Center Utrecht, 
      Utrecht, The Netherlands. a.braakenburg@umcutrecht.nl
FAU - de Valk, Harold W
AU  - de Valk HW
FAU - de Boer, Joke
AU  - de Boer J
FAU - Rothova, Aniki
AU  - Rothova A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Ophthalmol
JT  - American journal of ophthalmology
JID - 0370500
RN  - 0 (HLA-B27 Antigen)
SB  - IM
MH  - Acute Disease
MH  - Adult
MH  - Age of Onset
MH  - Female
MH  - Follow-Up Studies
MH  - HLA-B27 Antigen/*immunology
MH  - Humans
MH  - Male
MH  - Prognosis
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Sex Factors
MH  - Uveitis, Anterior/*immunology
MH  - Visual Acuity/physiology
EDAT- 2008/02/20 09:00
MHDA- 2008/04/02 09:00
CRDT- 2008/02/20 09:00
PHST- 2007/08/22 00:00 [received]
PHST- 2007/11/07 00:00 [revised]
PHST- 2007/11/09 00:00 [accepted]
PHST- 2008/02/20 09:00 [pubmed]
PHST- 2008/04/02 09:00 [medline]
PHST- 2008/02/20 09:00 [entrez]
AID - S0002-9394(07)00979-8 [pii]
AID - 10.1016/j.ajo.2007.11.009 [doi]
PST - ppublish
SO  - Am J Ophthalmol. 2008 Mar;145(3):472-9. doi: 10.1016/j.ajo.2007.11.009.