PMID- 18282763
OWN - NLM
STAT- MEDLINE
DCOM- 20080415
LR  - 20211020
IS  - 1096-0023 (Electronic)
IS  - 1043-4666 (Print)
IS  - 1043-4666 (Linking)
VI  - 41
IP  - 3
DP  - 2008 Mar
TI  - Elevated serum levels of IL-1ra in children with Plasmodium falciparum malaria 
      are associated with increased severity of disease.
PG  - 204-8
LID - 10.1016/j.cyto.2007.12.008 [doi]
AB  - Animal models suggest that cytokines and chemokines play a role in cerebral 
      malaria (CM) pathogenesis, but levels of a number of cytokines and chemokines 
      thought to be important in the pathogenesis of other infectious diseases are not 
      well characterized in children with CM. Serum levels of granulocyte-colony 
      stimulating factor (G-CSF), interleukin-1 receptor antagonist (IL-1ra), 
      interleukin-8 (IL-8) and monocyte chemoattractant protein-1 (MCP-1) were measured 
      in 77 children with CM, 70 children with uncomplicated malaria (UM) and 63 
      healthy community children (CC) in Uganda. Children with CM had elevated serum 
      levels of IL-1ra and IL-8 as compared to children with UM (median levels in 
      pg/ml, 11,891 vs. 6510, P=0.05, and 63 vs. 41, P=0.01, respectively). Children 
      with CM who died (n=4) had higher serum levels than survivors of IL-1ra (median 
      levels in pg/ml, 65,757 vs. 10,355, P=0.02), G-CSF (709 vs. 117, P=0.02), and 
      MCP-1 (1275 vs. 216, P=0.03) but not IL-8 (76 vs. 62, P=NS). Elevated IL-1ra 
      levels are associated with increased disease severity in children with malaria, 
      and very elevated levels of IL-1ra, G-CSF and MCP-1 are seen in children who die 
      of CM.
FAU - John, Chandy C
AU  - John CC
AD  - Global Pediatrics Program and Division of Pediatric Infectious Diseases, 
      Department of Pediatrics, University of Minnesota Medical School, 420 Delaware 
      Street, SE, 850 Mayo, MMC-296, Minneapolis, MN 55455, USA. ccj@umn.edu
FAU - Park, Gregory S
AU  - Park GS
FAU - Sam-Agudu, Nadia
AU  - Sam-Agudu N
FAU - Opoka, Robert O
AU  - Opoka RO
FAU - Boivin, Michael J
AU  - Boivin MJ
LA  - eng
GR  - R21 TW006794/TW/FIC NIH HHS/United States
GR  - R21 TW006794-01/TW/FIC NIH HHS/United States
GR  - (R21 TW-006794/TW/FIC NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20080220
PL  - England
TA  - Cytokine
JT  - Cytokine
JID - 9005353
RN  - 0 (Chemokines)
RN  - 0 (Cytokines)
RN  - 0 (Interleukin 1 Receptor Antagonist Protein)
SB  - IM
MH  - Chemokines/blood
MH  - Child
MH  - Child, Preschool
MH  - Cytokines/blood
MH  - Female
MH  - Humans
MH  - Interleukin 1 Receptor Antagonist Protein/*blood/physiology
MH  - Malaria, Cerebral/*diagnosis/immunology/*mortality
MH  - Malaria, Falciparum/*diagnosis/immunology/*mortality
MH  - Male
MH  - Severity of Illness Index
MH  - Uganda
PMC - PMC2323512
MID - NIHMS43597
EDAT- 2008/02/20 09:00
MHDA- 2008/04/16 09:00
PMCR- 2009/03/01
CRDT- 2008/02/20 09:00
PHST- 2007/08/10 00:00 [received]
PHST- 2007/12/11 00:00 [revised]
PHST- 2007/12/14 00:00 [accepted]
PHST- 2008/02/20 09:00 [pubmed]
PHST- 2008/04/16 09:00 [medline]
PHST- 2008/02/20 09:00 [entrez]
PHST- 2009/03/01 00:00 [pmc-release]
AID - S1043-4666(07)00531-5 [pii]
AID - 10.1016/j.cyto.2007.12.008 [doi]
PST - ppublish
SO  - Cytokine. 2008 Mar;41(3):204-8. doi: 10.1016/j.cyto.2007.12.008. Epub 2008 Feb 
      20.