PMID- 18283181
OWN - NLM
STAT- MEDLINE
DCOM- 20080312
LR  - 20181201
IS  - 1538-3652 (Electronic)
IS  - 0003-987X (Linking)
VI  - 144
IP  - 2
DP  - 2008 Feb
TI  - Toxic epidermal necrolysis due to zonisamide associated with reactivation of 
      human herpesvirus 6.
PG  - 232-5
LID - 10.1001/archdermatol.2007.48 [doi]
AB  - BACKGROUND: Recently, human herpesvirus 6 (HHV-6) reactivation has been 
      frequently observed in patients with drug-induced hypersensitivity syndrome or 
      drug rash with eosinophilia and systemic symptoms but not in patients with other 
      types of drug eruptions, eg, Stevens-Johnson syndrome and toxic epidermal 
      necrolysis (TEN). This finding suggests that there is a close relationship 
      between HHV-6 reactivation and drug-induced hypersensitivity syndrome. 
      OBSERVATIONS: A 71-year-old man who was not immunocompromised developed TEN 
      because of zonisamide therapy. After the onset of the rash, significant increases 
      in HHV-6 IgG titers and HHV-6 DNA levels were observed in the patient's whole 
      blood samples, indicating that an HHV-6 reactivation had occurred. Furthermore, 
      the patient's clinical manifestations of TEN appeared to recur concurrently with 
      HHV-6 reactivation. Conclusion Our case suggests that HHV-6 reactivation may also 
      occur in several types of drug eruptions, including Stevens-Johnson syndrome and 
      TEN.
FAU - Teraki, Yuichi
AU  - Teraki Y
AD  - Department of Dermatology, Saitama Medical University, Saitama Medical Center, 
      1981 Kamoda, Kawagoe, Saitama 350-8550, Japan. teraki@saitama-med.ac.jp
FAU - Murota, Haruhiko
AU  - Murota H
FAU - Izaki, Seiichi
AU  - Izaki S
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Arch Dermatol
JT  - Archives of dermatology
JID - 0372433
RN  - 0 (Anticonvulsants)
RN  - 0 (DNA, Viral)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Isoxazoles)
RN  - 459384H98V (Zonisamide)
SB  - IM
MH  - Aged
MH  - Anticonvulsants/*adverse effects
MH  - DNA, Viral/blood
MH  - Herpesvirus 6, Human/genetics/immunology/*physiology
MH  - Humans
MH  - Immunoglobulin G/blood
MH  - Isoxazoles/*adverse effects
MH  - Male
MH  - Stevens-Johnson Syndrome/blood/*etiology/pathology
MH  - *Virus Activation
MH  - Zonisamide
EDAT- 2008/02/20 09:00
MHDA- 2008/03/13 09:00
CRDT- 2008/02/20 09:00
PHST- 2008/02/20 09:00 [pubmed]
PHST- 2008/03/13 09:00 [medline]
PHST- 2008/02/20 09:00 [entrez]
AID - 144/2/232 [pii]
AID - 10.1001/archdermatol.2007.48 [doi]
PST - ppublish
SO  - Arch Dermatol. 2008 Feb;144(2):232-5. doi: 10.1001/archdermatol.2007.48.