PMID- 18283626
OWN - NLM
STAT- MEDLINE
DCOM- 20080417
LR  - 20090219
IS  - 0018-5043 (Print)
IS  - 0018-5043 (Linking)
VI  - 40
IP  - 2
DP  - 2008 Feb
TI  - Dendritic cell based immunotherapy--a promising therapeutic approach for 
      endocrine malignancies.
PG  - 89-98
LID - 10.1055/s-2007-1022549 [doi]
AB  - Dendritic cells (DCs) are the most potent antigen presenting cells in the human 
      organism. Ever since the discovery of their function in the self/nonself 
      discrimination, DCs have been seen as potential candidates for therapy in 
      malignant tumors. With the exception of differentiated thyroid cancer, endocrine 
      malignancies are rare tumors and apart from surgical intervention there is no 
      truly established method for their treatment. Therefore, the prognosis of many 
      endocrine carcinomas is still poor and new therapeutic options are needed. In the 
      last decade, different immunotherapeutic approaches have shown promising results 
      in other solid tumors. In recent studies, immunotherapy using DCs has been proven 
      to be safe and effective to induce antitumor immune responses leading to tumor 
      regression and even rejection of cancer in some cases. This review will summarize 
      the latest progress in DCs based immunotherapy with special focus on the limited 
      experience in endocrine malignancies. With regard to these tumors, it is of 
      special interest which antigens could serve as potential target antigens for 
      future trials. We also discuss what steps have to be taken to develop a better 
      immunotherapy in endocrine tumors.
FAU - Sbiera, S
AU  - Sbiera S
AD  - Department of Internal Medicine I, Endocrine and Diabetes Unit, University of 
      Wuerzburg, Wuerzburg, Germany.
FAU - Wortmann, S
AU  - Wortmann S
FAU - Fassnacht, M
AU  - Fassnacht M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Germany
TA  - Horm Metab Res
JT  - Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et 
      metabolisme
JID - 0177722
RN  - 0 (Antigens, Neoplasm)
SB  - IM
MH  - Antigens, Neoplasm/immunology
MH  - Clinical Trials as Topic
MH  - Combined Modality Therapy
MH  - Dendritic Cells/*immunology/physiology
MH  - Endocrine Gland Neoplasms/immunology/*therapy
MH  - Humans
MH  - *Immunotherapy
MH  - Neoplasms/immunology/therapy
RF  - 136
EDAT- 2008/02/20 09:00
MHDA- 2008/04/18 09:00
CRDT- 2008/02/20 09:00
PHST- 2008/02/20 09:00 [pubmed]
PHST- 2008/04/18 09:00 [medline]
PHST- 2008/02/20 09:00 [entrez]
AID - 10.1055/s-2007-1022549 [doi]
PST - ppublish
SO  - Horm Metab Res. 2008 Feb;40(2):89-98. doi: 10.1055/s-2007-1022549.