PMID- 18283627
OWN - NLM
STAT- MEDLINE
DCOM- 20080417
LR  - 20090219
IS  - 0018-5043 (Print)
IS  - 0018-5043 (Linking)
VI  - 40
IP  - 2
DP  - 2008 Feb
TI  - Dendritic cell subtypes and in vitro generation of dendritic cells.
PG  - 99-107
LID - 10.1055/s-2007-1022561 [doi]
AB  - Dendritic cells (DCs) are highly potent antigen-presenting cells crucial for the 
      innate and adaptive immune response and for maintaining immune tolerance towards 
      self-antigens. Although they share many common features, multiple DC subtypes 
      with different immune functions have been identified. Originally, DCs were 
      considered to be cells with purely myeloid origin. Recent studies have now 
      demonstrated that DCs can also develop from lymphatic progenitors. Various 
      cytokines and transcription factors are known to be responsible for the 
      development of DC subpopulation. Depending on the subpopulation and the 
      maturation state of these cells, they are either able to induce a broad cytotoxic 
      immune response, and therefore represent a promising tool for anticancer 
      vaccination therapies in humans or induce immune tolerance and are important 
      within the context of autoimmunity. This review will focus on recent advances on 
      the identification of different DC subpopulations including phenotypical and 
      functional differences and on recent developments on protocols for IN VITRO 
      generation of myeloid-derived DCs.
FAU - Jacobs, B
AU  - Jacobs B
AD  - Department of Endocrinology, Diabetes and Rheumatology, University Hospital 
      Duesseldorf, Duesseldorf, Germany.
FAU - Wuttke, M
AU  - Wuttke M
FAU - Papewalis, C
AU  - Papewalis C
FAU - Seissler, J
AU  - Seissler J
FAU - Schott, M
AU  - Schott M
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Germany
TA  - Horm Metab Res
JT  - Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et 
      metabolisme
JID - 0177722
RN  - 0 (Cytokines)
SB  - IM
MH  - Cell Differentiation
MH  - Cell Separation
MH  - Cytokines/immunology
MH  - Dendritic Cells/chemistry/*cytology/*immunology
MH  - Humans
MH  - Myeloid Progenitor Cells/cytology/immunology
RF  - 106
EDAT- 2008/02/20 09:00
MHDA- 2008/04/18 09:00
CRDT- 2008/02/20 09:00
PHST- 2008/02/20 09:00 [pubmed]
PHST- 2008/04/18 09:00 [medline]
PHST- 2008/02/20 09:00 [entrez]
AID - 10.1055/s-2007-1022561 [doi]
PST - ppublish
SO  - Horm Metab Res. 2008 Feb;40(2):99-107. doi: 10.1055/s-2007-1022561.