PMID- 18284049 OWN - NLM STAT- MEDLINE DCOM- 20080818 LR - 20141120 IS - 1009-3591 (Print) IS - 1009-3591 (Linking) VI - 13 IP - 12 DP - 2007 Dec TI - [The in vitro and in vivo experimental models of erectile nerve regeneration]. PG - 1059-63 AB - Neurogenic erectile dysfunction (NED) caused by pelvic floor surgeries/radiation therapies and associated with Parkinsons disease and diabetes remains a challenging healthcare issue. To facilitate NED research we have developed in vitro and in vivo experimental models. The in vitro model comprises the isolation, culture and treatment of rat major pelvic ganglia (MPG), which then produce outgrowing neurites whose length and molecular composition are indicative of the neurotrophic effect of the treatment agent. Through this approach we have confirmed that the brain-derived neurotrophic factor (BDNF) promotes nerve regeneration by activating the JAK/STAT signaling pathway. This has been further established by our in vivo model, which involves the transection or cruch of cavernous nerves and treatment with BDNF. FAU - Lin, Gui-Ting AU - Lin GT AD - Department of Urology, University of California, San Francisco, CA 94143, USA. FAU - Lue, Tom F AU - Lue TF FAU - Lin, Ching-Shwun AU - Lin CS LA - chi PT - English Abstract PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Review PL - China TA - Zhonghua Nan Ke Xue JT - Zhonghua nan ke xue = National journal of andrology JID - 101093592 SB - IM MH - Animals MH - Disease Models, Animal MH - Erectile Dysfunction/*physiopathology MH - Ganglia/*physiopathology MH - Humans MH - In Vitro Techniques MH - Male MH - *Nerve Regeneration MH - Pelvis/innervation MH - Penis/innervation/physiopathology RF - 20 EDAT- 2008/02/21 09:00 MHDA- 2008/08/19 09:00 CRDT- 2008/02/21 09:00 PHST- 2008/02/21 09:00 [pubmed] PHST- 2008/08/19 09:00 [medline] PHST- 2008/02/21 09:00 [entrez] PST - ppublish SO - Zhonghua Nan Ke Xue. 2007 Dec;13(12):1059-63.