PMID- 1828520
OWN - NLM
STAT- MEDLINE
DCOM- 19910718
LR  - 20190701
IS  - 0024-3205 (Print)
IS  - 0024-3205 (Linking)
VI  - 48
IP  - 26
DP  - 1991
TI  - Quinolinic acid lesion of nucleus accumbens reduces D1 but not D2 dopamine 
      receptors: an autoradiographic study.
PG  - 2535-42
AB  - Information concerning the cellular localization of dopamine receptor subtypes in 
      the nucleus accumbens (NAcc) was obtained using receptor autoradiographic 
      analysis. Unilateral, stereotaxic injection of the axon-sparing neurotoxin, 
      quinolinic acid, into the NAcc resulted in a prominent loss of dopamine D1 
      receptors (as labeled by [3H]SCH 23390). Contrarily, no appreciable decrement in 
      D2 receptors (labeled by [3H]raclopride) could be identified within the same 
      region of the NAcc. The findings support the view that accumbens D1 receptors are 
      located postsynaptically on neurons or their processes, while D2 receptors within 
      this nucleus are primarily located on afferent terminals.
FAU - Filloux, F
AU  - Filloux F
AD  - Department of Neurology, University of Utah School of Medicine, Salt Lake City 
      84132.
FAU - Richards, T J
AU  - Richards TJ
FAU - Huff, G F
AU  - Huff GF
FAU - Wamsley, J K
AU  - Wamsley JK
LA  - eng
GR  - 1 K08 HD00912-01/HD/NICHD NIH HHS/United States
GR  - DA05167/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Life Sci
JT  - Life sciences
JID - 0375521
RN  - 0 (Benzazepines)
RN  - 0 (Quinolinic Acids)
RN  - 0 (Receptors, Dopamine)
RN  - F6F0HK1URN (Quinolinic Acid)
SB  - IM
MH  - Animals
MH  - Autoradiography
MH  - Benzazepines/chemistry
MH  - Male
MH  - Nucleus Accumbens/*drug effects/pathology
MH  - Quinolinic Acid
MH  - Quinolinic Acids/*toxicity
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Receptors, Dopamine/*drug effects/metabolism
EDAT- 1991/01/01 00:00
MHDA- 1991/01/01 00:01
CRDT- 1991/01/01 00:00
PHST- 1991/01/01 00:00 [pubmed]
PHST- 1991/01/01 00:01 [medline]
PHST- 1991/01/01 00:00 [entrez]
AID - 0024-3205(91)90609-F [pii]
AID - 10.1016/0024-3205(91)90609-f [doi]
PST - ppublish
SO  - Life Sci. 1991;48(26):2535-42. doi: 10.1016/0024-3205(91)90609-f.