PMID- 18285323
OWN - NLM
STAT- MEDLINE
DCOM- 20080722
LR  - 20231213
IS  - 1460-2350 (Electronic)
IS  - 0268-1161 (Linking)
VI  - 23
IP  - 7
DP  - 2008 Jul
TI  - Endometrial dendritic cell populations during the normal menstrual cycle.
PG  - 1574-80
LID - 10.1093/humrep/den030 [doi]
AB  - BACKGROUND: Dendritic cells (DCs) are specialized antigen presenting cells that 
      are highly involved in the stimulation and modulation of the immune response 
      within mucosal surfaces, including the female reproductive tract. DCs have been 
      poorly characterized in the non-pregnant endometrium. METHODS: Hysterectomy 
      specimens were obtained from premenopausal women (n = 49) with histologically 
      normal endometrium. Endometrial sections were stained immunohistochemically using 
      antibodies for monoclonal mouse anti-human CD1a and CD83, two markers which are 
      specific for populations of immature and mature DCs, respectively. RESULTS: There 
      was a significantly higher density of endometrial CD1a+ DCs than CD83+ DCs 
      throughout the menstrual cycle (P < 0.001). The density of CD1a+ and CD83+ DCs 
      did not vary between the fundus and isthmus of the uterus. There was a 
      significant increase in the density of CD1a+ DCs, but not CD83+ DCs, in the basal 
      layer of the endometrium through the phases of the menstrual cycle. The density 
      of CD83+ was significantly greater in the basal layer compared with the 
      functional layer during both the proliferative (P = 0.004) and secretory phases 
      (P = 0.001), whereas for CD1a+ DCs, the greater density in the basal layer was 
      only observed in the secretory phase (P < 0.001). CONCLUSIONS: The highly 
      coordinated cyclical changes in DC populations during the normal menstrual cycle 
      reported in this study may be important for local regulatory mechanisms relevant 
      to menstruation and implantation; alterations in this normal profile may 
      contribute to the development of disturbances of function, fertility and even 
      benign gynaecological disease.
FAU - Schulke, L
AU  - Schulke L
AD  - Department of Obstetrics and Gynaecology, Queen Elizabeth II Research Institute 
      for Mothers and Infants, University of Sydney, Sydney 2006, Australia. 
      lschulke@med.usyd.edu.au
FAU - Manconi, F
AU  - Manconi F
FAU - Markham, R
AU  - Markham R
FAU - Fraser, I S
AU  - Fraser IS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080219
PL  - England
TA  - Hum Reprod
JT  - Human reproduction (Oxford, England)
JID - 8701199
RN  - 0 (Antigens, CD)
RN  - 0 (Antigens, CD1)
RN  - 0 (CD1a antigen)
RN  - 0 (Immunoglobulins)
RN  - 0 (Membrane Glycoproteins)
SB  - IM
MH  - Adult
MH  - Antigens, CD/analysis
MH  - Antigens, CD1/analysis
MH  - Dendritic Cells/*immunology
MH  - Endometrium/*cytology
MH  - Female
MH  - Humans
MH  - Hysterectomy
MH  - Immunoglobulins/analysis
MH  - Immunohistochemistry
MH  - Membrane Glycoproteins/analysis
MH  - Menstrual Cycle/*immunology
MH  - Middle Aged
MH  - Premenopause
MH  - CD83 Antigen
EDAT- 2008/02/21 09:00
MHDA- 2008/07/23 09:00
CRDT- 2008/02/21 09:00
PHST- 2008/02/21 09:00 [pubmed]
PHST- 2008/07/23 09:00 [medline]
PHST- 2008/02/21 09:00 [entrez]
AID - den030 [pii]
AID - 10.1093/humrep/den030 [doi]
PST - ppublish
SO  - Hum Reprod. 2008 Jul;23(7):1574-80. doi: 10.1093/humrep/den030. Epub 2008 Feb 19.