PMID- 18285638
OWN - NLM
STAT- MEDLINE
DCOM- 20080307
LR  - 20220309
IS  - 1348-9585 (Electronic)
IS  - 1341-9145 (Linking)
VI  - 50
IP  - 1
DP  - 2008
TI  - Body distribution of inhaled fluorescent magnetic nanoparticles in the mice.
PG  - 1-6
AB  - Reducing the particle size of materials is an efficient and reliable tool for 
      improving the bioavailability of a gene or drug delivery system. In fact, 
      nanotechnology helps in overcoming the limitations of size and can change the 
      outlook of the world regarding science. However, a potential harmful effect of 
      nanomaterial on workers manufacturing nanoparticles is expected in the workplace 
      and the lack of information regarding body distribution of inhaled nanoparticles 
      may pose serious problem. In this study, we addressed this question by studying 
      the body distribution of inhaled nanoparticles in mice using approximately 50-nm 
      fluorescent magnetic nanoparticles (FMNPs) as a model of nanoparticles through 
      nose-only exposure chamber system developed by our group. Scanning mobility 
      particle sizer (SMPS) analysis revealed that the mice were exposed to FMNPs with 
      a total particle number of 4.89 x 10(5) +/- 2.37 x 10(4)/cm(3) (low 
      concentration) and 9.34 x 10(5) +/- 5.11 x 10(4)/cm(3) (high concentration) for 4 
      wk (4 h/d, 5 d/wk). The body distribution of FMNPs was examined by magnetic 
      resonance imaging (MRI) and Confocal Laser Scanning Microscope (CLSM) analysis. 
      FMNPs were distributed in various organs, including the liver, testis, spleen, 
      lung and brain. T2-weighted spin-echo MR images showed that FMNPs could penetrate 
      the blood-brain-barrier (BBB). Application of nanotechnologies should not produce 
      adverse effects on human health and the environment. To predict and prevent the 
      potential toxicity of nanomaterials, therefore, extensive studies should be 
      performed under different routes of exposure with different sizes and shapes of 
      nanomaterials.
FAU - Kwon, Jung-Taek
AU  - Kwon JT
AD  - Laboratory of Toxicology, College of Veterinary Medicine, Seoul National 
      University, Seoul, Korea.
FAU - Hwang, Soon-Kyung
AU  - Hwang SK
FAU - Jin, Hua
AU  - Jin H
FAU - Kim, Dae-Seong
AU  - Kim DS
FAU - Minai-Tehrani, Arash
AU  - Minai-Tehrani A
FAU - Yoon, Hee-Jeong
AU  - Yoon HJ
FAU - Choi, Mansoo
AU  - Choi M
FAU - Yoon, Tae-Jong
AU  - Yoon TJ
FAU - Han, Duk-Young
AU  - Han DY
FAU - Kang, Young-Woon
AU  - Kang YW
FAU - Yoon, Byung-Il
AU  - Yoon BI
FAU - Lee, Jin-Kyu
AU  - Lee JK
FAU - Cho, Myung-Haing
AU  - Cho MH
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - J Occup Health
JT  - Journal of occupational health
JID - 9616320
RN  - 0 (Air Pollutants, Occupational)
SB  - IM
MH  - Air Pollutants, Occupational/*pharmacokinetics
MH  - Animals
MH  - Blood-Brain Barrier/physiology
MH  - Disease Models, Animal
MH  - Female
MH  - Fluorescence
MH  - Inhalation Exposure/*adverse effects
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Mice
MH  - Microscopy, Confocal
MH  - Nanoparticles/*adverse effects
MH  - *Occupational Exposure
EDAT- 2008/02/21 09:00
MHDA- 2008/03/08 09:00
CRDT- 2008/02/21 09:00
PHST- 2008/02/21 09:00 [pubmed]
PHST- 2008/03/08 09:00 [medline]
PHST- 2008/02/21 09:00 [entrez]
AID - JST.JSTAGE/joh/50.1 [pii]
AID - 10.1539/joh.50.1 [doi]
PST - ppublish
SO  - J Occup Health. 2008;50(1):1-6. doi: 10.1539/joh.50.1.