PMID- 18285674
OWN - NLM
STAT- MEDLINE
DCOM- 20080422
LR  - 20190727
IS  - 0040-8727 (Print)
IS  - 0040-8727 (Linking)
VI  - 214
IP  - 2
DP  - 2008 Feb
TI  - Allogeneic peripheral blood stem cell transplantation from related donors 
      mismatched at 2 HLA loci in the host-versus-graft direction.
PG  - 159-63
AB  - In allogeneic stem cell transplantation, immune reactions can occur in 2 
      directions. The recipient's lymphocytes can recognize the donor's cells as 
      "foreign" and attempt to kill them, which results in the host-versus-graft (HVG) 
      reaction that is commonly termed graft rejection. The other direction is the 
      graft-versus-host (GVH) reaction. When the recipient is homozygous at a 
      mismatched human leukocyte antigen (HLA) locus, HLA disparity is present only in 
      the former direction and not in the latter direction. If transplants harvested 
      from such an HVG-mismatched donor can be used to achieve stable engraftment with 
      minimal toxicity, then these donors can potentially be a useful alternative donor 
      source. Here, we report 2 patients (1 with acute myeloblastic leukemia and 
      another with lymphoblastic lymphoma) who were transplanted with peripheral blood 
      stem cells (PBSCs) obtained from related donors mismatched at 2 HLA loci in the 
      HVG direction but completely matched in the GVH direction. Our conditioning 
      regimen, consisting of busulfan, cyclophosphamide, low-dose total body 
      irradiation (TBI) (4 Gy), and fludarabine, achieved successful engraftment with 
      an acceptable level of regimen-related toxicity. Our experience suggests that 
      PBSC transplantation with an HVG-mismatched related donor and an appropriate 
      conditioning regimen may be a therapeutic option for patients in whom early 
      transplantation is desirable.
FAU - Ando, Toshihiko
AU  - Ando T
AD  - Third Department of Internal Medicine, Yamaguchi University School of Medicine, 
      Ube, Japan.
FAU - Yujiri, Toshiaki
AU  - Yujiri T
FAU - Nomiyama, Jun
AU  - Nomiyama J
FAU - Mitani, Noriyuki
AU  - Mitani N
FAU - Seguchi, Masato
AU  - Seguchi M
FAU - Matsubara, Atsushi
AU  - Matsubara A
FAU - Tanizawa, Yukio
AU  - Tanizawa Y
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Japan
TA  - Tohoku J Exp Med
JT  - The Tohoku journal of experimental medicine
JID - 0417355
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Adult
MH  - Female
MH  - Graft vs Host Reaction/*immunology
MH  - HLA Antigens/*immunology
MH  - *Histocompatibility Testing
MH  - Humans
MH  - Middle Aged
MH  - *Peripheral Blood Stem Cell Transplantation
MH  - *Tissue Donors
MH  - Transplantation, Homologous
EDAT- 2008/02/21 09:00
MHDA- 2008/04/23 09:00
CRDT- 2008/02/21 09:00
PHST- 2008/02/21 09:00 [pubmed]
PHST- 2008/04/23 09:00 [medline]
PHST- 2008/02/21 09:00 [entrez]
AID - JST.JSTAGE/tjem/214.159 [pii]
AID - 10.1620/tjem.214.159 [doi]
PST - ppublish
SO  - Tohoku J Exp Med. 2008 Feb;214(2):159-63. doi: 10.1620/tjem.214.159.