PMID- 18285706
OWN - NLM
STAT- MEDLINE
DCOM- 20081118
LR  - 20200930
IS  - 1555-8576 (Electronic)
IS  - 1538-4047 (Linking)
VI  - 7
IP  - 5
DP  - 2008 May
TI  - Chemotherapy targeting regional lymphatic tissues to treat rabbits bearing VX2 
      tumor in the mammary glands.
PG  - 721-5
AB  - Lymph node status is one of the decisive prognostic factors in breast cancer. 
      Chemotherapy targeting regional lymphatic tissues has emerged as a promising 
      approach for the treatment of malignancies with high tendency to disseminate 
      lymphatically. In this study, rabbits bearing well-developed VX2 tumors in the 
      mammary gland received carboplatin-activated carbon suspension (CP-CH) 
      administered subcutaneously (s.c.), carboplatin solution (CP-Sol) s.c., CP-Sol 
      intravenously (i.v.), or a sham therapy, respectively, 6 weeks after tumor 
      implantation. The platinum concentrations in breast tumors, axillary lymph nodes 
      and distant metastases were determined by Zeeman atomic absorption spectrometry 
      (AAS). Therapeutic effects were assessed in terms of tumor and node volume ratio, 
      cell proliferation and necrosis. Compared to CP-CH or CP-Sol s.c., CP-Sol i.v. 
      exhibited more marked cytotoxic efficacy on breast tumor and distant metastases. 
      In contrast, CP-CH s.c. produced much higher drug concentrations and more evident 
      antitumor activities in axillary nodes, as demonstrated by the inhibited node 
      growth, declined mRNA level of proliferating cell nuclear antigen (PCNA), and 
      more extensive tumor necrosis. Based on these data, we recommend lymphatic 
      chemotherapy to be used as an effective component of the approach to the systemic 
      treatment on breast cancer patients with positive lymph nodes.
FAU - Chen, Jianghao
AU  - Chen J
AD  - Department of Vascular and Endocrine Surgery, Xijing Hospital, Fourth Military 
      Medical University, Xi'an, Shaanxi Province, China. 
      chenjh@fmmu.edu.cn/vascular@fmmu.edu.cn
FAU - Yao, Qing
AU  - Yao Q
FAU - Li, Dong
AU  - Li D
FAU - Zhang, Bin
AU  - Zhang B
FAU - Li, Liwen
AU  - Li L
FAU - Wang, Ling
AU  - Wang L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080512
PL  - United States
TA  - Cancer Biol Ther
JT  - Cancer biology & therapy
JID - 101137842
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Proliferating Cell Nuclear Antigen)
RN  - 7440-44-0 (Carbon)
RN  - BG3F62OND5 (Carboplatin)
SB  - IM
MH  - Animals
MH  - Antineoplastic Agents/pharmacology
MH  - Breast Neoplasms/*drug therapy
MH  - Carbon/*chemistry
MH  - Carboplatin/pharmacology/*therapeutic use
MH  - Chemistry, Pharmaceutical/methods
MH  - Disease Models, Animal
MH  - Drug Design
MH  - Female
MH  - Lymph Nodes/pathology
MH  - Necrosis
MH  - Neoplasm Metastasis
MH  - Proliferating Cell Nuclear Antigen/metabolism
MH  - Rabbits
MH  - Spectrophotometry, Atomic/methods
EDAT- 2008/02/21 09:00
MHDA- 2008/11/19 09:00
CRDT- 2008/02/21 09:00
PHST- 2008/02/21 09:00 [pubmed]
PHST- 2008/11/19 09:00 [medline]
PHST- 2008/02/21 09:00 [entrez]
AID - 5721 [pii]
AID - 10.4161/cbt.7.5.5721 [doi]
PST - ppublish
SO  - Cancer Biol Ther. 2008 May;7(5):721-5. doi: 10.4161/cbt.7.5.5721. Epub 2008 May 
      12.