PMID- 18285715
OWN - NLM
STAT- MEDLINE
DCOM- 20080623
LR  - 20211020
IS  - 1525-4135 (Print)
IS  - 1944-7884 (Electronic)
IS  - 1525-4135 (Linking)
VI  - 47
IP  - 5
DP  - 2008 Apr 15
TI  - Antiretroviral drug resistance and risk behavior among recently HIV-infected men 
      who have sex with men.
PG  - 639-43
LID - 10.1097/QAI.0b013e3181684c3d [doi]
AB  - OBJECTIVES: Examine associations among behaviors including substance use during 
      sexual encounters, and transmitted HIV drug resistance in recently HIV-infected 
      men who have sex with men (MSM). METHODS: Between 2002 and 2006, 117 recently 
      HIV-infected MSM completed questionnaires regarding their 3 most recent sexual 
      partners. Serum samples were tested for the presence of genotypic and phenotypic 
      HIV drug resistance. Logistic regression analysis was used to assess the 
      association of substance use, behaviors, and resistance to at least 1 class of 
      HIV drugs. RESULTS: The mean age of participants was 35 years; 71% identified as 
      white and 19% as Hispanic. Sixty (51%) reported substance use during sexual 
      activity in the past 12 months. A total of 12.5% of 112 had genotypic drug 
      resistance to at least 1 class of antiretroviral medications, and 14% of 117 had 
      phenotypic drug resistance. Substances used during sexual activity associated 
      with phenotypic drug resistance in multivariate models included any substance use 
      (adjusted odds ratio [aOR] = 4.21, 95% confidence interval [CI]: 1.13 to 15.68), 
      polysubstance use (aOR = 5.64, 95% CI: 1.62 to 19.60), methamphetamine (aOR = 
      4.00, 95% CI: 1.19 to 13.38), 3,4-methylenedioxy-N-methylamphetamine 
      (MDMA)/Ecstasy (aOR = 7.16, 95% CI: 1.40 to 36.59), and gamma-hydroxyl butyrate 
      (GHB) (aOR = 6.98, 95% CI: 1.82 to 26.80). The genotype analysis was similar. 
      CONCLUSIONS: Among these recently HIV-infected MSM, methamphetamine use during 
      sexual activity and use of other substances, such as MDMA and GHB, was associated 
      with acquired drug-resistant virus. No other behaviors associated with 
      acquisition of drug-resistant HIV.
FAU - Gorbach, Pamina M
AU  - Gorbach PM
AD  - Department of Epidemiology, School of Public Health, University of California, 
      Los Angeles, Los Angeles, CA 90095-7353, USA. pgorbach@ucla.edu
FAU - Drumright, Lydia N
AU  - Drumright LN
FAU - Javanbakht, Marjan
AU  - Javanbakht M
FAU - Pond, Sergei L
AU  - Pond SL
FAU - Woelk, Christopher H
AU  - Woelk CH
FAU - Daar, Eric S
AU  - Daar ES
FAU - Little, Susan J
AU  - Little SJ
LA  - eng
GR  - R01 DA022116/DA/NIDA NIH HHS/United States
GR  - R24 AI106039/AI/NIAID NIH HHS/United States
GR  - U01 AI043638/AI/NIAID NIH HHS/United States
PT  - Journal Article
PL  - United States
TA  - J Acquir Immune Defic Syndr
JT  - Journal of acquired immune deficiency syndromes (1999)
JID - 100892005
RN  - 44RAL3456C (Methamphetamine)
SB  - IM
MH  - Adult
MH  - *Drug Resistance, Viral
MH  - HIV/*drug effects
MH  - HIV Infections/epidemiology/*virology
MH  - *Homosexuality, Male
MH  - Humans
MH  - Male
MH  - Methamphetamine
MH  - Risk Factors
MH  - Risk-Taking
MH  - Substance Abuse, Intravenous/epidemiology/virology
MH  - Substance-Related Disorders/*epidemiology
MH  - Surveys and Questionnaires
PMC - PMC4153748
MID - NIHMS602728
EDAT- 2008/02/21 09:00
MHDA- 2008/06/24 09:00
PMCR- 2014/09/03
CRDT- 2008/02/21 09:00
PHST- 2008/02/21 09:00 [pubmed]
PHST- 2008/06/24 09:00 [medline]
PHST- 2008/02/21 09:00 [entrez]
PHST- 2014/09/03 00:00 [pmc-release]
AID - 10.1097/QAI.0b013e3181684c3d [doi]
PST - ppublish
SO  - J Acquir Immune Defic Syndr. 2008 Apr 15;47(5):639-43. doi: 
      10.1097/QAI.0b013e3181684c3d.