PMID- 18286239
OWN - NLM
STAT- MEDLINE
DCOM- 20080804
LR  - 20131121
IS  - 0163-4984 (Print)
IS  - 0163-4984 (Linking)
VI  - 123
IP  - 1-3
DP  - 2008 Summer
TI  - Blood lead levels and increased bronchial responsiveness.
PG  - 41-6
LID - 10.1007/s12011-008-8099-6 [doi]
AB  - The immune system is one of the targets most sensitive to lead toxicity, and the 
      association between lead exposure and serum immunoglobulin E (IgE) has been 
      published. Recent studies also reported that lead caused the development of 
      IgE-mediated allergy. To investigate whether blood lead levels contribute to 
      other allergic conditions, we examined the effect of blood lead on bronchial 
      responsiveness (BR) in the general population. We performed a cross-sectional 
      study with adults aged 19 to 58 years in a Korean community. Blood lead level and 
      the methacholine provocation test were performed. The overall mean blood lead 
      level was 2.9 microg/dl, and the mean BR index was 1.14. The percent of subjects 
      with clinically diagnosed asthma was 21 (4%) and there was no difference in blood 
      lead level with and without asthma. In the multiple regression model, the 
      elevation of blood lead level was related to the increase of BR after adjusting 
      for age, sex, height, smoking status, and the presence of asthma. Blood lead 
      level was significantly associated with increased BR that came from the elevation 
      of the IgE level with lead exposure. Lead may contribute to the increase of 
      asthma and other allergic conditions.
FAU - Min, Jin-Young
AU  - Min JY
AD  - School of Public Health and Institute of Health and Environment, Seoul National 
      University, Chongno-gu Yongeun-dong 28, Seoul, 110-799, South Korea.
FAU - Min, Kyoung-Bok
AU  - Min KB
FAU - Kim, Rokho
AU  - Kim R
FAU - Cho, Sung-Il
AU  - Cho SI
FAU - Paek, Domyung
AU  - Paek D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080220
PL  - United States
TA  - Biol Trace Elem Res
JT  - Biological trace element research
JID - 7911509
RN  - 0W5ETF9M2K (Methacholine Chloride)
RN  - 2P299V784P (Lead)
SB  - IM
MH  - Adult
MH  - Asthma/blood/diagnosis/physiopathology
MH  - Bronchial Hyperreactivity/*blood/physiopathology
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Korea
MH  - Lead/*blood
MH  - Male
MH  - Methacholine Chloride/administration & dosage
MH  - Middle Aged
EDAT- 2008/02/21 09:00
MHDA- 2008/08/05 09:00
CRDT- 2008/02/21 09:00
PHST- 2007/12/11 00:00 [received]
PHST- 2008/01/21 00:00 [accepted]
PHST- 2008/02/21 09:00 [pubmed]
PHST- 2008/08/05 09:00 [medline]
PHST- 2008/02/21 09:00 [entrez]
AID - 10.1007/s12011-008-8099-6 [doi]
PST - ppublish
SO  - Biol Trace Elem Res. 2008 Summer;123(1-3):41-6. doi: 10.1007/s12011-008-8099-6. 
      Epub 2008 Feb 20.