PMID- 18288087
OWN - NLM
STAT- MEDLINE
DCOM- 20080707
LR  - 20150813
IS  - 1532-6535 (Electronic)
IS  - 0009-9236 (Linking)
VI  - 84
IP  - 1
DP  - 2008 Jul
TI  - COX inhibitors downregulate PDE4D expression in a clinical model of inflammatory 
      pain.
PG  - 39-42
LID - 10.1038/sj.clpt.6100501 [doi]
AB  - Tumor necrosis factor-alpha (TNF-alpha) has a central role in inflammation and is 
      modulated by prostaglandin E(2) (PGE(2)) and cyclic adenosine monophosphate 
      (cAMP). Using microarray, quantitative real-time polymerase chain reaction 
      (qRT-PCR), and protein detection techniques, we showed that ketorolac and 
      rofecoxib had no significant effect on TNF-alpha gene expression in oral mucosal 
      biopsies 3 h after surgery. They both, however, downregulated the gene and 
      protein expression of phosphodiesterase type 4 (PDE4D), which might represent a 
      novel mechanism contributing to their analgesic and anti-inflammatory effects.
FAU - Wang, X-M
AU  - Wang XM
AD  - Pain Research Section, National Institute of Nursing Research, National 
      Institutes of Health, Bethesda, Maryland, USA.
FAU - Hamza, M
AU  - Hamza M
FAU - Gordon, S M
AU  - Gordon SM
FAU - Wahl, S M
AU  - Wahl SM
FAU - Dionne, R A
AU  - Dionne RA
LA  - eng
GR  - Intramural NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, N.I.H., Intramural
DEP - 20080220
PL  - United States
TA  - Clin Pharmacol Ther
JT  - Clinical pharmacology and therapeutics
JID - 0372741
RN  - 0 (Cyclooxygenase Inhibitors)
RN  - 0 (Phosphodiesterase 3 Inhibitors)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - EC 3.1.4.17 (Cyclic Nucleotide Phosphodiesterases, Type 3)
RN  - EC 3.1.4.17 (Cyclic Nucleotide Phosphodiesterases, Type 4)
RN  - EC 3.1.4.17 (PDE4D protein, human)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Cyclic Nucleotide Phosphodiesterases, Type 3/*biosynthesis/genetics
MH  - Cyclic Nucleotide Phosphodiesterases, Type 4
MH  - Cyclooxygenase Inhibitors/*pharmacology/therapeutic use
MH  - Down-Regulation/*drug effects/physiology
MH  - Gene Expression Regulation, Enzymologic/*drug effects/physiology
MH  - Humans
MH  - Inflammation/drug therapy/enzymology/genetics
MH  - Pain/drug therapy/*enzymology/genetics
MH  - *Phosphodiesterase 3 Inhibitors
MH  - Tumor Necrosis Factor-alpha/biosynthesis/genetics
EDAT- 2008/02/22 09:00
MHDA- 2008/07/08 09:00
CRDT- 2008/02/22 09:00
PHST- 2008/02/22 09:00 [pubmed]
PHST- 2008/07/08 09:00 [medline]
PHST- 2008/02/22 09:00 [entrez]
AID - 6100501 [pii]
AID - 10.1038/sj.clpt.6100501 [doi]
PST - ppublish
SO  - Clin Pharmacol Ther. 2008 Jul;84(1):39-42. doi: 10.1038/sj.clpt.6100501. Epub 
      2008 Feb 20.