PMID- 18288203
OWN - NLM
STAT- MEDLINE
DCOM- 20080829
LR  - 20080715
IS  - 1523-1747 (Electronic)
IS  - 0022-202X (Linking)
VI  - 128
IP  - 8
DP  - 2008 Aug
TI  - A protective effect of glutathione-S-transferase GSTP1*Val(105) against 
      polymorphic light eruption.
PG  - 1901-5
LID - 10.1038/jid.2008.14 [doi]
AB  - Polymorphic light eruption (PLE) is a common skin disease, susceptibility to 
      which is genetically determined. The prevalence of PLE is significantly increased 
      in patients with lupus erythematosus (LE) including subacute cutaneous lupus 
      erythematosus (SCLE) and discoid lupus erythematosus (DLE), which may reflect a 
      common genetic background. Experimental evidence supports a role for reactive 
      oxygen species (ROS) in the pathogenesis of PLE, and the family of 
      glutathione-S-transferase (GST) enzymes exerts a critical physiological role in 
      cellular protection against this oxidative damage. Our aim was to look for 
      association between the functional GST gene polymorphisms and PLE, SCLE, and DLE 
      in a case-control study. The carrier frequency of GSTP1 Val(105) in subjects with 
      PLE was 40%, significantly lower than the carrier frequency in controls (54%, 
      P=0.019), although significance was lost on correction for multiple testing. 
      However, the carrier frequency of the GSTP1 Val(105) allele in combined cutaneous 
      LE (SCLE and DLE) patients with PLE was 42%, significantly lower than in those 
      without PLE (72%), which did survive correction (corrected P=0.043). We have 
      identified evidence supporting a protective GSTP1 allele, the first genetic 
      association to be reported for PLE. This supports a role for ROS in the 
      pathogenesis of PLE and may provide a therapeutic target for future treatment of 
      this common, often disabling, condition.
FAU - Millard, Thomas P
AU  - Millard TP
AD  - Department of Photobiology, St John's Institute of Dermatology, London, UK. 
      tom.millard@glos.nhs.uk
FAU - Fryer, Anthony A
AU  - Fryer AA
FAU - McGregor, Jane M
AU  - McGregor JM
LA  - eng
PT  - Journal Article
DEP - 20080221
PL  - United States
TA  - J Invest Dermatol
JT  - The Journal of investigative dermatology
JID - 0426720
RN  - 0 (Reactive Oxygen Species)
RN  - EC 2.5.1.- (glutathione S-transferase T1)
RN  - EC 2.5.1.18 (GSTM3 protein, human)
RN  - EC 2.5.1.18 (GSTP1 protein, human)
RN  - EC 2.5.1.18 (Glutathione S-Transferase pi)
RN  - EC 2.5.1.18 (Glutathione Transferase)
RN  - EC 2.5.1.18 (glutathione S-transferase M1)
SB  - IM
MH  - Alleles
MH  - Case-Control Studies
MH  - Genotype
MH  - Glutathione S-Transferase pi/*genetics
MH  - Glutathione Transferase/genetics
MH  - Humans
MH  - Lupus Erythematosus, Cutaneous/enzymology/*genetics
MH  - Lupus Erythematosus, Discoid/enzymology/*genetics
MH  - Photosensitivity Disorders/*enzymology/genetics
MH  - Polymorphism, Genetic/*genetics
MH  - Reactive Oxygen Species/metabolism
MH  - Skin Diseases/*genetics
EDAT- 2008/02/22 09:00
MHDA- 2008/08/30 09:00
CRDT- 2008/02/22 09:00
PHST- 2008/02/22 09:00 [pubmed]
PHST- 2008/08/30 09:00 [medline]
PHST- 2008/02/22 09:00 [entrez]
AID - S0022-202X(15)33963-4 [pii]
AID - 10.1038/jid.2008.14 [doi]
PST - ppublish
SO  - J Invest Dermatol. 2008 Aug;128(8):1901-5. doi: 10.1038/jid.2008.14. Epub 2008 
      Feb 21.