PMID- 18289017
OWN - NLM
STAT- MEDLINE
DCOM- 20090316
LR  - 20220321
IS  - 1875-5739 (Electronic)
IS  - 1567-2026 (Linking)
VI  - 5
IP  - 1
DP  - 2008 Feb
TI  - Angelica injection reduces cognitive impairment during chronic cerebral 
      hypoperfusion through brain-derived neurotrophic factor and nerve growth factor.
PG  - 13-20
AB  - The current study investigated whether chronic cerebral hypoperfusion produced by 
      permanent bilateral common carotid artery occlusion (2-vessel occlusion (2-VO)) 
      induced cognitive impairment and whether angelica injections alleviated the 
      impairment. Furthermore, the study examined whether 2-VO altered the expression 
      patterns of brain-derived neurotrophic factor (BDNF) and nerve growth factor 
      (NGF) in the hippocampus of rats and whether angelica injections attenuated the 
      alteration. Rats were divided into four groups to receive either 2-VO surgery or 
      sham surgery followed by either angelica injections or saline injections for 
      eight weeks. Spatial learning in Morris water maze and the expression patterns of 
      BDNF and NGF in the hippocampus of all rats were examined. The results showed 
      that 2-VO significantly impaired spatial learning and memory, and angelica 
      injections significantly reversed the learning and memory impairment. 
      Furthermore, 2-VO resulted in significantly decreased BDNF protein, NGF protein, 
      and NGF mRNA expression in the hippocampus. Angelica injections significantly 
      attenuated the decreased expression. Moreover, spatial learning in Morris water 
      maze was positively correlated to the expression of BDNF and NGF in the 
      hippocampus. Thus, angelica injections might alleviate cognitive impairment 
      during chronic cerebral hypoperfusion through BDNF and NGF.
FAU - Zheng, Ping
AU  - Zheng P
AD  - Department of Neurology, Zhongnan Hospital, Wuhan University, Wuhan City, China.
FAU - Zhang, Junjian
AU  - Zhang J
FAU - Liu, Hanxing
AU  - Liu H
FAU - Xu, Xiaojuan
AU  - Xu X
FAU - Zhang, Xiaolian
AU  - Zhang X
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United Arab Emirates
TA  - Curr Neurovasc Res
JT  - Current neurovascular research
JID - 101208439
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Plant Preparations)
SB  - IM
MH  - Analysis of Variance
MH  - Angelica/*chemistry
MH  - Animals
MH  - Brain Ischemia
MH  - Brain-Derived Neurotrophic Factor/genetics/*metabolism
MH  - Carotid Artery Diseases/complications
MH  - Cognition Disorders/*drug therapy/etiology/pathology
MH  - Gene Expression Regulation/drug effects
MH  - Hippocampus/drug effects/metabolism
MH  - Linear Models
MH  - Male
MH  - Maze Learning/drug effects
MH  - Nerve Growth Factors/genetics/*metabolism
MH  - Phytotherapy/*methods
MH  - Plant Preparations/*therapeutic use
MH  - Rats
MH  - Rats, Wistar
EDAT- 2008/02/22 09:00
MHDA- 2009/03/17 09:00
CRDT- 2008/02/22 09:00
PHST- 2008/02/22 09:00 [pubmed]
PHST- 2009/03/17 09:00 [medline]
PHST- 2008/02/22 09:00 [entrez]
AID - 10.2174/156720208783565636 [doi]
PST - ppublish
SO  - Curr Neurovasc Res. 2008 Feb;5(1):13-20. doi: 10.2174/156720208783565636.