PMID- 18289377
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20220408
IS  - 1743-7075 (Electronic)
IS  - 1743-7075 (Linking)
VI  - 5
DP  - 2008 Feb 20
TI  - Eggs modulate the inflammatory response to carbohydrate restricted diets in 
      overweight men.
PG  - 6
LID - 10.1186/1743-7075-5-6 [doi]
AB  - BACKGROUND: Carbohydrate restricted diets (CRD) consistently lower glucose and 
      insulin levels and improve atherogenic dyslipidemia [decreasing triglycerides and 
      increasing HDL cholesterol (HDL-C)]. We have previously shown that male subjects 
      following a CRD experienced significant increases in HDL-C only if they were 
      consuming a higher intake of cholesterol provided by eggs compared to those 
      individuals who were taking lower concentrations of dietary cholesterol. Here, as 
      a follow up of our previous study, we examined the effects of eggs (a source of 
      both dietary cholesterol and lutein) on adiponectin, a marker of insulin 
      sensitivity, and on inflammatory markers in the context of a CRD. METHODS: Twenty 
      eight overweight men [body mass index (BMI) 26-37 kg/m2] aged 40-70 y consumed an 
      ad libitum CRD (% energy from CHO:fat:protein = 17:57:26) for 12 wk. Subjects 
      were matched by age and BMI and randomly assigned to consume eggs (EGG, n = 15) 
      (640 mg additional cholesterol/day provided by eggs) or placebo (SUB, n = 13) (no 
      additional dietary cholesterol). Fasting blood samples were drawn before and 
      after the intervention to assess plasma lipids, insulin, adiponectin and markers 
      of inflammation including C-reactive protein (CRP), tumor necrosis factor-alpha 
      (TNF-alpha), interleukin-8 (IL-8), monocyte chemoattractant protein-1 (MCP-1), 
      intercellular adhesion molecule-1 (ICAM-1), and vascular cell adhesion 
      molecule-1(VCAM-1). RESULTS: Body weight, percent total body fat and trunk fat 
      were reduced for all subjects after 12 wk (P < 0.0001). Increases in adiponectin 
      were also observed (P < 0.01). Subjects in the EGG group had a 21% increase in 
      this adipokine compared to a 7% increase in the SUB group (P < 0.05). Plasma CRP 
      was significantly decreased only in the EGG group (P < 0.05). MCP-1 levels were 
      decreased for the SUB group (P < 0.001), but unchanged in the EGG group. VCAM-1, 
      ICAM-1, TNF-alpha, and IL-8 were not modified by CRD or eggs. CONCLUSION: A CRD 
      with daily intake of eggs decreased plasma CRP and increased plasma adiponectin 
      compared to a CRD without eggs. These findings indicate that eggs make a 
      significant contribution to the anti-inflammatory effects of CRD, possibly due to 
      the presence of cholesterol, which increases HDL-C and to the antioxidant lutein 
      which modulates certain inflammatory responses.
FAU - Ratliff, Joseph C
AU  - Ratliff JC
AD  - Department of Nutritional Sciences, University of Connecticut, Storrs, CT, USA. 
      maria-luz.fernandez@uconn.edu.
FAU - Mutungi, Gisella
AU  - Mutungi G
FAU - Puglisi, Michael J
AU  - Puglisi MJ
FAU - Volek, Jeff S
AU  - Volek JS
FAU - Fernandez, Maria Luz
AU  - Fernandez ML
LA  - eng
PT  - Journal Article
DEP - 20080220
PL  - England
TA  - Nutr Metab (Lond)
JT  - Nutrition & metabolism
JID - 101231644
PMC - PMC2265719
EDAT- 2008/02/22 09:00
MHDA- 2008/02/22 09:01
PMCR- 2008/02/20
CRDT- 2008/02/22 09:00
PHST- 2007/10/02 00:00 [received]
PHST- 2008/02/20 00:00 [accepted]
PHST- 2008/02/22 09:00 [pubmed]
PHST- 2008/02/22 09:01 [medline]
PHST- 2008/02/22 09:00 [entrez]
PHST- 2008/02/20 00:00 [pmc-release]
AID - 1743-7075-5-6 [pii]
AID - 10.1186/1743-7075-5-6 [doi]
PST - epublish
SO  - Nutr Metab (Lond). 2008 Feb 20;5:6. doi: 10.1186/1743-7075-5-6.