PMID- 18289476
OWN - NLM
STAT- MEDLINE
DCOM- 20080605
LR  - 20131121
IS  - 1008-8830 (Print)
IS  - 1008-8830 (Linking)
VI  - 10
IP  - 1
DP  - 2008 Feb
TI  - [Relationship between brain-derived neurotrophic factor and birth weight in 
      neonates].
PG  - 70-2
AB  - OBJECTIVE: Recent research has shown that brain-derived neurotrophic factor 
      (BDNF) can improve obesity. This study aimed to explore the relationship between 
      BDNF and birth weight by measuring BDNF levels in the umbilical cord blood of 
      neonates. METHODS: Based on birth weight, 51 first-born full-term healthy 
      neonates were classified into 3 groups: small for gestational age (SGA, n=8), 
      appropriate for gestational age (AGA, n=31) and large for gestational age (LGA, 
      n=12). Height and birth weight as well as umbilical concentrations of BDNF, 
      leptin, insulin, total cholesterol and triglyceride were determined. RESULTS: 
      BDNF level in the SGA group (19980.00 +/- 5470.54 pg/mL) was significantly higher 
      than that in the AGA (10598.00 +/- 6295.71 pg/mL) and LGA (7508.57 +/- 3767.81 
      pg/mL) groups (P <0.05). There was no significant difference in the BDNF level 
      between the AGA and LGA groups. Stepwise regression analysis showed that the 
      value of BDNF was negatively correlated with birth weight and BMI of neonates, 
      but had no correlation with leptin and insulin levels. Leptin levels showed 
      positive correlations with birth weight and BMI of neonates. There were no 
      significant differences in total cholesterol and triglyceride levels among the 
      three groups. CONCLUSIONS: BDNF is closely correlated to birth weight but not 
      correlated with leptin and insulin in neonates.
FAU - Wang, Cheng-Feng
AU  - Wang CF
AD  - Department of Pediatrics, Fuzhou General Hospital of Nanjing Military Command, 
      Fuzhou 350025, China. wcf5613@sina.com
FAU - Ye, Li-Yan
AU  - Ye LY
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhongguo Dang Dai Er Ke Za Zhi
JT  - Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics
JID - 100909956
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Insulin)
RN  - 0 (Leptin)
RN  - 0 (Triglycerides)
RN  - 97C5T2UQ7J (Cholesterol)
SB  - IM
MH  - *Birth Weight
MH  - Body Mass Index
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Cholesterol/blood
MH  - Humans
MH  - Infant, Newborn
MH  - Insulin/blood
MH  - Leptin/blood
MH  - Triglycerides/blood
EDAT- 2008/02/22 09:00
MHDA- 2008/06/06 09:00
CRDT- 2008/02/22 09:00
PHST- 2008/02/22 09:00 [pubmed]
PHST- 2008/06/06 09:00 [medline]
PHST- 2008/02/22 09:00 [entrez]
AID - 1008-8830(2008)01-0070-03 [pii]
PST - ppublish
SO  - Zhongguo Dang Dai Er Ke Za Zhi. 2008 Feb;10(1):70-2.