PMID- 18289765
OWN - NLM
STAT- MEDLINE
DCOM- 20080514
LR  - 20080317
IS  - 0300-483X (Print)
IS  - 0300-483X (Linking)
VI  - 246
IP  - 2-3
DP  - 2008 Apr 18
TI  - Allergy adjuvant effect of particles from wood smoke and road traffic.
PG  - 124-31
LID - 10.1016/j.tox.2008.01.001 [doi]
AB  - There is growing evidence that in addition to augmenting the severity of asthma 
      and allergic diseases, particulate air pollution also increases the incidence of 
      allergy and asthma. We studied the adjuvant effect of particles from wood smoke 
      and road traffic on the immune response to the allergen ovalbumin (OVA). OVA with 
      and without particles was injected into one hind footpad of Balb/cA mice. All 
      particles together with OVA significantly increased the level of OVA-specific 
      immunoglobulin E (IgE) in serum, compared to groups given OVA or particles alone. 
      Reference diesel exhaust particles (DEP) with OVA induced the highest levels of 
      IgE, whereas no clear difference was observed between particles from road traffic 
      and wood smoke. Road traffic particles collected in the autumn induced higher IgE 
      values with OVA than corresponding particles collected during the winter season 
      when studded tires are used, suggesting that studded tire-generated road pavement 
      particles have less allergy adjuvant activity than exhaust particles. Compared to 
      OVA or particles alone, all particles with OVA increased popliteal lymph node 
      cell numbers, cell proliferation, ex vivo secretion of IL-4 and IL-10 after ConA 
      stimulation, and the expression of several cell surface molecules (CD19, MHC 
      class II, CD86 and CD23). Wood smoke particles with OVA induced somewhat higher 
      cellular responses than road traffic particles, but less than DEP with OVA which 
      seemed to be the most potent particle in inducing cellular as well as antibody 
      responses. Thus, wood smoke particles had about the same capacity to enhance 
      allergic sensitization as road traffic particles, but less than diesel exhaust 
      particles.
FAU - Samuelsen, Mari
AU  - Samuelsen M
AD  - Division of Environmental Medicine, Norwegian Institute of Public Health, P.O.Box 
      4404 Nydalen, NO-0403 Oslo, Norway. mari.samuelsen@fhi.no
FAU - Nygaard, Unni Cecilie
AU  - Nygaard UC
FAU - Lovik, Martinus
AU  - Lovik M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080115
PL  - Ireland
TA  - Toxicology
JT  - Toxicology
JID - 0361055
RN  - 0 (Adjuvants, Immunologic)
RN  - 0 (Air Pollutants)
RN  - 0 (Allergens)
RN  - 0 (Antigens, CD)
RN  - 0 (Cytokines)
RN  - 0 (Drug Combinations)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Smoke)
RN  - 0 (Soot)
RN  - 0 (Vehicle Emissions)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 9006-59-1 (Ovalbumin)
SB  - IM
MH  - Adjuvants, Immunologic/*pharmacology
MH  - Air Pollutants/*pharmacology
MH  - Allergens/*pharmacology
MH  - Animals
MH  - Antigens, CD/metabolism
MH  - Cell Count
MH  - Cell Proliferation/drug effects
MH  - Cytokines/metabolism
MH  - Disease Models, Animal
MH  - Drug Combinations
MH  - Female
MH  - Hindlimb
MH  - Immunoglobulin E/*blood
MH  - Immunoglobulin G/blood
MH  - Local Lymph Node Assay
MH  - Lymph Nodes/drug effects/immunology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Ovalbumin/immunology
MH  - Particle Size
MH  - Smoke
MH  - Soot/pharmacology
MH  - Vehicle Emissions
MH  - Wood
EDAT- 2008/02/22 09:00
MHDA- 2008/05/15 09:00
CRDT- 2008/02/22 09:00
PHST- 2007/11/01 00:00 [received]
PHST- 2007/12/21 00:00 [revised]
PHST- 2008/01/03 00:00 [accepted]
PHST- 2008/02/22 09:00 [pubmed]
PHST- 2008/05/15 09:00 [medline]
PHST- 2008/02/22 09:00 [entrez]
AID - S0300-483X(08)00007-3 [pii]
AID - 10.1016/j.tox.2008.01.001 [doi]
PST - ppublish
SO  - Toxicology. 2008 Apr 18;246(2-3):124-31. doi: 10.1016/j.tox.2008.01.001. Epub 
      2008 Jan 15.