PMID- 18289832
OWN - NLM
STAT- MEDLINE
DCOM- 20080813
LR  - 20220310
IS  - 0920-9964 (Print)
IS  - 0920-9964 (Linking)
VI  - 101
IP  - 1-3
DP  - 2008 Apr
TI  - Low serum levels of brain-derived neurotrophic factor and epidermal growth factor 
      in patients with chronic schizophrenia.
PG  - 58-66
LID - 10.1016/j.schres.2008.01.017 [doi]
AB  - Neurotrophic factors (NFs) play a pivotal role in the development of the central 
      nervous system. They are thus also suspected of being involved in the etiology of 
      schizophrenia. Previous studies reported a decreased level of serum brain-derived 
      neurotrophic factor (BDNF) in schizophrenia, whereas the association of epidermal 
      growth factor (EGF) with this illness remains controversial. Using a two-site 
      enzyme immunoassay, we conducted the simultaneous measurement of serum BDNF and 
      EGF levels in a group of patients with chronic schizophrenia (N=74) and a group 
      of normal controls matched in age, body mass index, smoking habit and sex (N=87). 
      We found that, compared to normal controls, patients with chronic schizophrenia 
      exhibited lower serum levels of both BDNF and EGF across all ages examined (21-59 
      years). The serum levels of BDNF and EGF were negatively correlated in the 
      controls (r=-0.387, P=0.0002) but not in the patients. Clinical parameters such 
      as duration of illness and psychiatric rating scale also showed no robust 
      correlations with the NF levels. Collectively, these results suggest that 
      pervasive, abnormal signaling of NFs underlies the pathophysiology of chronic 
      schizophrenia.
FAU - Ikeda, Yumiko
AU  - Ikeda Y
AD  - Department of Pharmacology, Nippon Medical School, 1-1-5, Sendagi, Bunkyo-ku, 
      Tokyo 113-8602, Japan. y-ikeda@nms.ac.jp
FAU - Yahata, Noriaki
AU  - Yahata N
FAU - Ito, Itsuo
AU  - Ito I
FAU - Nagano, Masatoshi
AU  - Nagano M
FAU - Toyota, Tomoko
AU  - Toyota T
FAU - Yoshikawa, Takeo
AU  - Yoshikawa T
FAU - Okubo, Yoshiro
AU  - Okubo Y
FAU - Suzuki, Hidenori
AU  - Suzuki H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080304
PL  - Netherlands
TA  - Schizophr Res
JT  - Schizophrenia research
JID - 8804207
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 62229-50-9 (Epidermal Growth Factor)
SB  - IM
MH  - Adult
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Chronic Disease
MH  - Epidermal Growth Factor/*blood
MH  - Female
MH  - Humans
MH  - Immunoenzyme Techniques/methods
MH  - Male
MH  - Middle Aged
MH  - Schizophrenia/*blood
MH  - Statistics, Nonparametric
EDAT- 2008/02/22 09:00
MHDA- 2008/08/14 09:00
CRDT- 2008/02/22 09:00
PHST- 2007/09/24 00:00 [received]
PHST- 2008/01/07 00:00 [revised]
PHST- 2008/01/16 00:00 [accepted]
PHST- 2008/02/22 09:00 [pubmed]
PHST- 2008/08/14 09:00 [medline]
PHST- 2008/02/22 09:00 [entrez]
AID - S0920-9964(08)00067-4 [pii]
AID - 10.1016/j.schres.2008.01.017 [doi]
PST - ppublish
SO  - Schizophr Res. 2008 Apr;101(1-3):58-66. doi: 10.1016/j.schres.2008.01.017. Epub 
      2008 Mar 4.